SICONG WANG1, RUIJIN LIU2, QIUYUAN HAN2, KAIJIANG YU3,*
BIOCELL, Vol.46, No.1, pp. 149-158, 2022, DOI:10.32604/biocell.2021.013027
- 29 September 2021
Abstract Acute kidney injury (AKI), commonly occurring as complications of sepsis, cardiac surgery, and liver or kidney
transplantation, is a critical care syndrome. It is well known that lipopolysaccharide (LPS) shock is a common triggering
factor for AKI. This study is aimed to examine the effect of flavonoid compound hispidulin on LPS-induced AKI. For
this, renal tubular epithelial cell HK-2 was treated with LPS to establish an in vitro model of AKI. The effect of
hispidulin on HK-2 cell viability was examined using CCK-8 assay. Cell apoptosis was determined by TUNEL and flow
cytometry. Apoptosis marker proteins… More >
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