KEWEI CHENG¹, LEI SHI¹, CAIWEN SHI¹, SHUANSHUAN XIE², CHANGHUI WANG^2,*

BIOCELL, Vol.48, No.8, pp. 1209-1221, 2024, DOI:10.32604/biocell.2024.049626

Abstract Objective: To explore the role of polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) in lung adenocarcinoma (LUAD). Methods: Bioinformatics tools were utilized to examine the clinical profile of PKHD1L1 and chromobox protein homolog 7 (CBX7) in LUAD. The Cell Counting Kit-8, colony formation, terminal deoxynucleotidyl transferase dUTP nick end labeling, Transwell, and wound-healing assays were carried out to assess the proliferative, apoptotic, invasive, and migrative capacities of the cells. Furthermore, the interrelation between PKHD1L1 and CBX7 was validated using a co-immunoprecipitation assay. A LUAD mice model was constructed by subcutaneous injection of A549 cells.… More >

QING YIN¹, CAIHONG LIU¹, WENYING JIANG¹, HAIHUI GONG¹, CHUNYUN LI^1,2,3,*, ZUPING HE^1,2,3,*

BIOCELL, Vol.47, No.1, pp. 33-39, 2023, DOI:10.32604/biocell.2023.023567

Abstract Yes-associated protein 1 (YAP1) is a downstream effector of the Hippo signaling pathway, and it is involved in tumorigenesis, tissue repair, growth, and development. In this review, the biological roles and the mechanisms of YAP1 in mediating stem cell fate decisions are discussed, including cell proliferation, differentiation, and apoptosis. In general, YAP1 promotes the proliferation and differentiation of stem cells, including embryonic stem cells and adult stem cells. It inhibits apoptosis by binding to the transcription factors, e.g., transcriptional enhanced associate domain (TEAD), Smad, runt-related transcription factor 1/2, p73, p63, and Erb84, to maintain tissue More >