Feng Xi*, Jianghao Ye†
Oncology Research, Vol.23, No.1-2, pp. 53-59, 2015, DOI:10.3727/096504015X14459480491740
Abstract Hexokinase 2 (HK2) has been identified as an oncogene in some malignant diseases such as breast cancer
and ovarian cancer. However, the role of HK2 in lung cancer remains unclear. In this study, we explored the
functional role of HK2 in lung cancer cell proliferation and tumorigenesis and determine its expression profile
in lung cancer. HK2 expression was increased in primary lung cancer tissues of patients. Knocking down HK2
expression by small interfering RNA (siRNA) inhibited cell proliferation in lung cancer cells and nude mice.
Thus, HK2 is required for sustained proliferation and survival of More >
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