Hai-tao Geng*, Rui-juan Cao*, Lei Cheng†, Chun-yuan Liu†
Oncology Research, Vol.25, No.7, pp. 1039-1046, 2017, DOI:10.3727/096504016X14813914187138
Abstract Hepatocyte cell adhesion molecule (hepaCAM), a new type of CAM, belongs to the immunoglobulin superfamily. Recently, hepaCAM was reported to be implicated in cancer development, and many researchers
investigated its biological function in the tumorigenesis of various cancers. However, what kind of role
hepaCAM plays in colorectal cancer (CRC) remains unknown. In this study, we found that hepaCAM was
downregulated in CRC tissues and cell lines. Overexpression of hepaCAM inhibited CRC cell proliferation,
migration, and invasion in vitro. Furthermore, the tumorigenesis assay showed that increased expression of
hepaCAM suppressed CRC tumor growth and metastasis in More >
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