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    ARTICLE

    Heme Oxygenase-1 Inhibits Tumor Metastasis Mediated by Notch1 Pathway in Murine Mammary Carcinoma

    Qiang Li*†1, Qi Liu*1, Wanpeng Cheng*, Huiyan Wei*, Wenqian Jiang*, Fang E*, Yuan Yu*, Jianfeng Jin*, Chaoxia Zou*‡

    Oncology Research, Vol.27, No.6, pp. 643-651, 2019, DOI:10.3727/096504018X15415906335771

    Abstract Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results revealed that overexpression of HO-1 strongly inhibits the lung metastasis of 4T1 cells. In in vitro analysis, associated indices for epithelial–mesenchymal transition (EMT), migration, and proliferation of 4T1 cells were evaluated. The results show that HO-1 inhibits EMT, migration, and proliferation of 4T1 cells. In addition, More >

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