Gangcan Li, Yanping Song, Yunjie Zhang, Hao Wang, Jia Xie
Oncology Research, Vol.24, No.2, pp. 109-116, 2016, DOI:10.3727/096504016X14611963142254
Abstract Acute myeloid leukemia (AML) is the most lethal hematological malignancy, and the occurrence of chemoresistance prevents the achievement of complete remission following the standard therapy. MicroRNAs have
been extensively investigated as critical regulators of hematopoiesis and leukemogenesis, and they represent
a promising strategy for AML therapy. In this study, we identified miR-34b as a novel regulator in myeloid
proliferation and apoptosis of leukemic cells. We found that miR-34b was developmentally upregulated in
plasma and myeloid cells of healthy subjects, while it was significantly reduced in blood samples of patients
with AML and AML cell lines.… More >
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