Yuri A. Piven1, Danila V. Sorokin2, Nastassia A. Varabyeva1, Alexandra L. Mikhaylova2, Fedor B. Bogdanov2, Elena V. Shafranovskaya1, Raman M. Puzanau3, Fedor A. Lakhvich1, Alexander M. Scherbakov2,4,*
Oncology Research, Vol.33, No.12, pp. 4049-4072, 2025, DOI:10.32604/or.2025.067832
- 27 November 2025
Abstract Background: The most aggressive forms of breast cancer are characterized by independence from steroid hormones but a strong dependence on growth factors. In such cancer cells, oncogenic receptors, including human epidermal growth factor receptor 2 (HER2), are activated, and their targeted inhibition represents an attractive therapeutic strategy. The study aimed to develop small-molecule potential dual heat shock protein 90 (HSP90)-HER2 inhibitors and evaluate them as anticancer agents in HER2-positive cells. Methods: The research project involved obtaining a series of compounds with potential dual inhibitory activity against HSP90 and HER2 by targeted organic synthesis, which was… More >
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