Hao Lu1, Chaoyang Sun1, Ting Zhou, Bo Zhou, Ensong Guo, Wanying Shan, Meng Xia, Kezhen Li, Danhui Weng, Li Meng, Xiaoyan Xu, Junbo Hu, Ding Ma, Gang Chen
Oncology Research, Vol.23, No.3, pp. 119-128, 2015, DOI:10.3727/096504015X14496932933656
Abstract Drug resistance is the leading cause of chemotherapy failure in the treatment of ovarian cancer. So far, little is
known about the mechanism of chemoresistance in ovarian cancer. In this study, we explored the mechanism
that HSP27 was involved in cisplatin resistance of ovarian cancer both in vitro and clinically. HSP27 protein
was found to be upregulated and expressed in cisplatin-resistant ovarian cancer cell line C13*, and HSP27
siRNA transfection reversed the chemoresistance of C13*. We found that HSP27 exerted its chemoresistant
role by inhibiting p21 transferring from the nucleus to the plasma through the More >
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