Xiangrui Meng*1, Xiaoqi Chen†1, Peng Lu‡, Wang Ma*, Dongli Yue*, Lijie Song*, Qingxia Fan*
Oncology Research, Vol.25, No.2, pp. 215-223, 2017, DOI:10.3727/096504016X14732772150541
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant cancers with high mortality
around the world. However, the regulatory mechanism of ESCC carcinogenesis is not completely known. Here
we demonstrate the novel role of miR-202 in regulating ESCC cell apoptosis. The analysis of data obtained
from the GEO database showed that the expression of miR-202 is aberrantly decreased in tumor tissue from
ESCC patients and cultured ESCC cell lines. After transfection with miR-202 mimic or inhibitor, the apoptotic capacity of ESCC cells was significantly increased by miR-202 overexpression but reduced by miR-202… More >
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