Ping Chen*, Qing Jin*, Qiang Fu*, Peidong You*, Xi Jiang*, Qin Yuan*, Huifang Huang†
Oncology Research, Vol.24, No.4, pp. 215-223, 2016, DOI:10.3727/096504016X14634208143021
Abstract This study aimed to investigate the role of the PI3K/Akt signaling pathway in multidrug resistance of acute
myeloid leukemia (AML) cells induced by cocultured stromal cells. Human AML cell lines HL-60 and U937
were adhesion cocultured with human bone marrow stromal cell line HS-5 cells. Such coculturing induced
HL-60 and U937 cells resistant to chemotherapeutic drugs including daunorubicin (DNR), homoharringtonine
(HHT), and cytosine arabinoside (Ara-C). The coculturing-induced resistance of AML cells to DNR, HHT, and
Ara-C can be partially reversed by inhibition of the PI3K/Akt signaling pathway. Clinically, AML patients with
a low level of More >
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