Jianing Xu*†, Qiyu Bo‡, Xiang Zhang§, Dapeng Lei†, Jue Wang*, Xinliang Pan†
Oncology Research, Vol.28, No.3, pp. 311-319, 2020, DOI:10.3727/096504020X15801233454611
Abstract Hypopharyngeal squamous cell carcinoma (HSCC) remains one of the most lethal malignancies in the head and
neck. Long noncoding RNA (lncRNA) HOXA11-AS is proven to function as an oncogene and a therapeutic
target in various tumors. Our previous study and others have demonstrated that HOXA11-AS is one of the
most upregulated lncRNAs in HSCC. However, the role of HOXA11-AS in HSCC has not yet been identified.
The current study demonstrated that the expression of HOXA11-AS was significantly upregulated in HSCC
tumors and was positively associated with lymph node metastasis. Moreover, functional experiments revealed
that HOXA11-AS knockdown suppressed the proliferation and… More >
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