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  • Open Access

    ARTICLE

    Understanding Psychosocial Determinants of Adolescent Bullying in Türkiye

    Ramazan İnci1,*, Davut Açar2, Osman Tayyar Çelik3, Yunus Tunç4

    International Journal of Mental Health Promotion, Vol.28, No.1, 2026, DOI:10.32604/ijmhp.2025.072072 - 28 January 2026

    Abstract Background: Bullying during adolescence is shaped by numerous psychosocial factors such as family dynamics, attachment, and peer relationships. This study aims to examine parental acceptance-rejection, attachment styles, and social exclusion factors as key psychosocial variables predicting bullying behavior in adolescents. Methods: In a cross-sectional study conducted with 349 high school students in Hakkari, Türkiye. Data were collected using the Olweus Bullying Scale, the Parental Acceptance-Rejection Scale, the Social Exclusion Scale, and the Three-Dimensional Attachment Styles Scale. Independent samples t-tests, one-way ANOVAs, Pearson correlations, and hierarchical regression analyses were performed. Results: Research findings reveal that peer bullying varies… More >

  • Open Access

    ARTICLE

    Cognitive NFIDC-FRBFNN Control Architecture for Robust Path Tracking of Mobile Service Robots in Hospital Settings

    Huda Talib Najm1,2, Ahmed Sabah Al-Araji3, Nur Syazreen Ahmad1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.071837 - 29 January 2026

    Abstract Mobile service robots (MSRs) in hospital environments require precise and robust trajectory tracking to ensure reliable operation under dynamic conditions, including model uncertainties and external disturbances. This study presents a cognitive control strategy that integrates a Numerical Feedforward Inverse Dynamic Controller (NFIDC) with a Feedback Radial Basis Function Neural Network (FRBFNN). The robot’s mechanical structure was designed in SolidWorks 2022 SP2.0 and validated under operational loads using finite element analysis in ANSYS 2022 R1. The NFIDC-FRBFNN framework merges proactive inverse dynamic compensation with adaptive neural learning to achieve smooth torque responses and accurate motion control.… More >

  • Open Access

    ARTICLE

    Modeling Hepatitis B and Alcohol Effects on Liver Cirrhosis Progression

    Zia Ur Rahman1, Nigar Ali1,2, Dragan Pamucar3, Imtiaz Ahmad1,2, Haci Mehmet Baskonus2,*, Naseer Ul Haq1, Zeeshan Ali4

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.070268 - 29 January 2026

    Abstract Hepatitis B Virus (HBV) infection and heavy alcohol consumption are the two primary pathogenic causes of liver cirrhosis. In this paper, we proposed a deterministic mathematical model and a logistic equation to investigate the dynamics of liver cirrhosis progression as well as to explain the implications of variations in alcohol consumption on chronic hepatitis B patients, respectively. The intricate interactions between liver cirrhosis, recovery, and treatment dynamics are captured by the model. This study aims to show that alcohol consumption by Hepatitis B-infected individuals accelerates liver cirrhosis progression while treatment of acutely infected individuals reduces… More >

  • Open Access

    ARTICLE

    PIK3R1 as a Gastric Cancer Biomarker Linked to CD73+ Treg-Mediated Immunosuppression

    Bu Zou1,#, Yi-En Xu2,#, Hui-Chan He3, Zu-Lu Ye2, Da-Lei Zhou2, Cai-Yun He2,*, Chan Huang4,*

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069453 - 19 January 2026

    Abstract Objectives: Gastric cancer (GC) remains a major global health concern, and Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1), a regulatory subunit of the PI3K signaling pathway, may play a critical yet underexplored role in GC progression. This study aimed to investigate the prognostic significance of PIK3R1 in GC and its association with the tumor immune microenvironment. Methods: PIK3R1 expression and its clinical relevance were analyzed using datasets from GC patients who underwent gastrectomy, including cohorts from The Cancer Genome Atlas (TCGA) and the Sun Yat-sen University Cancer Center (SYSUCC). Prognostic models integrating PIK3R1 expression with clinical parameters… More >

  • Open Access

    ARTICLE

    PNP as a Metabolic and Prognostic Driver of Breast Cancer Aggressiveness: Insights from Patient Tissue and Cell Models

    Sarra B. Shakartalla1,2,3, Iman M. Talaat1,2,4,*, Nival Ali1, Shahenaz S. Salih1,5, Zainab M. Al Shareef1,2, Noura Alkhayyal6, Riyad Bendardaf2,7,*, Sameh S. M. Soliman1,8,*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

    Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

  • Open Access

    ARTICLE

    AGPAT3 Regulates Immune Microenvironment in Osteosarcoma via Lysophosphatidic Acid Metabolism

    Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

    Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

  • Open Access

    ARTICLE

    ResghostNet: Boosting GhostNet with Residual Connections and Adaptive-SE Blocks

    Yuang Chen1,2, Yong Li1,*, Fang Lin1,2, Shuhan Lv1,2, Jiaze Jiang1,2

    CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-18, 2026, DOI:10.32604/cmc.2025.070990 - 09 December 2025

    Abstract Aiming at the problem of potential information noise introduced during the generation of ghost feature maps in GhostNet, this paper proposes a novel lightweight neural network model called ResghostNet. This model constructs the Resghost Module by combining residual connections and Adaptive-SE Blocks, which enhances the quality of generated feature maps through direct propagation of original input information and selection of important channels before cheap operations. Specifically, ResghostNet introduces residual connections on the basis of the Ghost Module to optimize the information flow, and designs a weight self-attention mechanism combined with SE blocks to enhance feature More >

  • Open Access

    ARTICLE

    Construction of Synergistic and Efficient Flame-Retardant Polyamide 6 Composites by Incorporating Aluminum Diethylphosphinate and Fly Ash

    Ruiping Wang, Chuang He, Shuo Zhang, Miaojun Xu*, Zhuo Wang, Xiaoli Li*, Bin Tao, Suliang Gao, Bin Li*

    Journal of Polymer Materials, Vol.42, No.4, pp. 1035-1049, 2025, DOI:10.32604/jpm.2025.073108 - 26 December 2025

    Abstract The fabrication of highly flame-retardant polyamide 6 (PA6) composites is of great significance for expanding their practical applications. Herein, a new flame-retardant system (ADP/FA) was developed by combining aluminum diethylphosphinate (ADP) with excellent flame retardancy and fly ash (FA), an economical and environmentally friendly industrial waste. Due to the synergistic flame-retardant effect of ADP/FA in the condensed phase and gas phase, the PA6 composite containing only 11 wt% of ADP/FA (mass ratio 93:7) obtained vertical burning (UL-94) tests V-0 rating with a limiting oxygen index (LOI) of 30.9%. To obtain the same flame-retardant level of… More > Graphic Abstract

    Construction of Synergistic and Efficient Flame-Retardant Polyamide 6 Composites by Incorporating Aluminum Diethylphosphinate and Fly Ash

  • Open Access

    ARTICLE

    Psychosocial Functioning and Quality of Life of Recipients in Pediatric Heart Transplant

    Min Zeng1, Fan Yang1, Jie Huang2, Zhongkai Liao2, Sheng Liu3, Xu Wang1,*

    Congenital Heart Disease, Vol.20, No.5, pp. 581-589, 2025, DOI:10.32604/chd.2025.070100 - 30 November 2025

    Abstract Background: Psychosocial functioning and quality of life (QoL) are strongly associated with outcomes in pediatric heart transplant recipients. The data in pediatric transplantation, however, is limited. This study aims to investigate the associations of perioperative anxiety and depression with postoperative complications, sociodemographic and clinical characteristics. Methods: This observational, analytical, longitudinal study included 42 pediatric participants aged 8 to 16 years old. Preoperative psychological assessments were completed by 36 children, the remaining 6 were unable to participate due to invasive ventilation, extracorporeal membrane oxygenation (ECMO), and physical debilitation. Postoperatively, all 42 subjects completed the psychosocial evaluations. Data… More >

  • Open Access

    ARTICLE

    DADS Regulates EMT and Chemotherapy Resistance by Inhibiting RORα/β-Catenin Signaling through PKCα-Dependent Phosphorylation in Gastric Cancer

    Yizhen Zhang1,2,#, Juan Li1,3,#, Huanqing Liu1,4,#, Hong Xia1, Jian Su1,5, Fang Liu1, Bo Su6,*, Qi Su1,*

    Oncology Research, Vol.33, No.12, pp. 3869-3886, 2025, DOI:10.32604/or.2025.068689 - 27 November 2025

    Abstract Objectives: Gastric cancer (GC) is often associated with high invasiveness, epithelial-mesenchymal transition (EMT), and resistance to 5-fluorouracil (5-FU), highlighting the need for novel therapeutic targets. This study explored whether diallyl disulfide (DADS) upregulates retinoic acid-related orphan receptor alpha (ROR) to weaken the protein kinase C alpha (PKC)/RORα-mediated RORα/β-catenin pathway, thereby inhibiting GC cell invasion, epithelial-mesenchymal transition (EMT), and enhancing 5-FU sensitivity. Methods: Human GC cell lines MGC-803 and SGC7901 were treated with DADS, RORα agonist SR1078/antagonist T0901317, and PKCα agonist TPA/antagonist GO6976. Cell proliferation (MTT), migration (scratch assay), invasion (Transwell), protein expression (Western blot), protein… More >

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