KURT SARTORIUS^1,2,3,*, BENN SARTORIUS⁴, CHERIE WINKLER⁵, ANIL CHUTURGOON², ANNA KRAMVIS¹, PING AN⁵, WEIGANG ZHANG⁶, YUNJIE LU^3,6,7,*

BIOCELL, Vol.48, No.11, pp. 1543-1567, 2024, DOI:10.32604/biocell.2024.055505 - 07 November 2024

Abstract Hepatitis B-associated hepatocellular carcinoma (HBV-HCC) remains an intractable high-mortality solid tumor cancer that accounted for 42% of global HCC cases in 2019. Despite some developments in systemic therapy, only a small subset of late-stage HCC patients responds positively to recently developed therapeutic innovations. MicroRNAs (miRNAs) act as an ancillary epigenetic system that can regulate genome expression in all cancer pathways including HCC. The molecular mechanisms of miRNA regulation in cancer pathogenesis offered researchers a new approach that was widely hoped would translate into miRNA-based drugs and diagnostics. Thirty years on, miRNA-based diagnostic and therapeutic agents… More >

Martha L. Sánchez^1,*, G. Capote²

Journal of Renewable Materials, Vol.12, No.10, pp. 1791-1810, 2024, DOI:10.32604/jrm.2024.055122 - 23 October 2024

Abstract The construction sector is one of the main sources of pollution, due to high energy consumption and the toxic substances generated during the processing and use of traditional materials. The production of cement, steel, and other conventional materials impacts both ecosystems and human health, increasing the demand for ecological and biodegradable alternatives. In this paper, we analyze the properties of panels made from a combination of plant fibers and castor oil resin, analyzing the viability of their use as construction material. For the research, orthogonal fabrics made with waste plant fibers supplied by a company… More >

Jili Cai¹, Junyi Zhou¹, Hangyu Chen¹, Liang Huang¹, Wenming Jiang¹, Jie Liu¹, Zhongwei Li¹, Chao Cai^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.3, pp. 1-2, 2024, DOI:10.32604/icces.2024.011946

Abstract Effectively obtaining tritium is one of the essential issues to realize commercial and controlled nuclear fusion [1]. Conventional lithium-containing ceramic tritium breeders with pebble bed configurations in fusion reactors have shown insurmountable structural drawbacks weakening tritium extraction, including inherently low packing fractions, extensive stress concentrations, and low thermal conductivity. Therefore, extensive efforts have been devoted to enhancing tritium extraction by improving the design of tritium breeders and addressing structural drawbacks [2-4]. In this study, porous block configurations were proposed to replace conventional pebble bed configurations for the ceramic tritium breeder. Utilizing fluid-solid coupled heat transfer… More >

Abderrahim Boutasknit^1,2,3, Mohamed Anli³, Rachid Lahlali^4,*, Abdelilah Meddich^2,3,5,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2227-2249, 2024, DOI:10.32604/phyton.2024.055629 - 30 September 2024

Abstract Applying organic waste and inorganic additives during composting can be an effective and easy-to-control strategy for optimizing humification, maturation, and the availability of essential mineral elements in compost. In this respect, this study aims to evaluate the effect of organic (olive-mill waste and horse manure) and inorganic (phosphogypsum) additives on the evolution of maturity indices, aromatic compounds, and nutrient availability during composting. Four mixtures [horse manure + green waste (M1), olive-mill + green waste (M2), sewage-sludge + phos-phogypsum + green waste (M3), and green waste (M4)] were carried out. Physicochemical (temperature, pH, phosphorus, nitrogen, and… More >

Deqing Han, Yong Zeng^*, Jintong Gu, Bin Yan

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.10, pp. 2393-2415, 2024, DOI:10.32604/fdmp.2024.053114 - 23 September 2024

Abstract To accurately predict the film thickness distribution during dynamic spraying performed with air guns and support accordingly the development of intelligent spray painting, the spray problem was analyzed numerically. In particular, the Eulerian-Eulerian approach was employed to calculate the paint atomization and film deposition process. Different spray heights, spray angles, spray gun movement speeds, spray trajectory curvature radii, and air pressure values were considered. Numerical simulation results indicate that the angle of spray painting significantly affects the velocity of droplets near the spray surface. With an increase in the spraying angle, spraying height and spray… More >

Yuan Huang¹, Jia Wei², Peigang Liu², Yan Zhu², Tianbao Lin², Zhiqiang Lv², Yijun Li³, Mei Zong³, Yun Zhou³, Junshan Gao^1,*, Zilong Xu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1995-2008, 2024, DOI:10.32604/phyton.2024.052353 - 30 August 2024

Abstract To provide a scientific basis for controlling mulberry bacterial blight in Bazhong, Sichuan, China (BSC), this study aimed to isolate and purify pathogenic bacteria from diseased branches of mulberry trees in the region and to clarify their taxonomic status using morphological observation, physiological and biochemical detection, molecular-level identification, and the construction of a phylogenetic tree. A total of 218 bacterial strains were isolated from samples of diseased mulberry branches. Of these, 7 strains were identified as pathogenic bacteria based on pathogenicity tests conducted in accordance with Koch’s postulates. Preliminary findings from the analysis of the More >

Yu Wang^1,2, Mengyang Ma^1,2,*, Yong Long^1,2, Qingxiang Zhao^1,2, Zhifei Cheng^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.8, pp. 1773-1784, 2024, DOI:10.32604/fdmp.2024.048695 - 06 August 2024

Abstract Shrinkage-induced cracking is a common issue in concrete structures, where the formation of cracks not only affects the aesthetic appearance of concrete but also potentially reduces its durability and strength. In this study, the effect of ceramsite sand addition on the properties of a ternary system of cement-ground granulated blast furnace slag (GGBFS)-phosphogypsum (PG) is investigated. In particular, the fluidity, rheology, hydration heat, compressive strength, autogenous shrinkage, and drying shrinkage of the considered mortar specimens are analyzed. The results indicate that an increase in PG content leads to a decrease in fluidity, higher viscosity, lower More >

TINGTING LIU^#, DINGYOU GUO^#, JIANSHE WEI^*

BIOCELL, Vol.48, No.8, pp. 1155-1179, 2024, DOI:10.32604/biocell.2024.051518 - 02 August 2024

Abstract In China, Parkinson’s disease (PD) is the second most prevalent central nervous system (CNS) degenerative illness affecting middle-aged and older persons. Movement disorders including resting tremor, bradykinesia, myotonia, postural instability, and gait instability are the predominant clinical symptoms. The two main types of PD are sporadic and familial, with sporadic PD being the more prevalent of the two. The environment, genetics, mitochondrial dysfunction, oxidative stress, inflammation, protein aggregation and misfolding, loss of trophic factors, cell death, and gut microbiota may all have a role in the etiology of PD. PD is inversely connected with other More >

JUN-FENG ZHAO^1,†, YI-RAN JIANG^2,†, TIAN-LIN GUO¹, YONG-QING JIAO^1,*, XUN WANG^1,*

BIOCELL, Vol.48, No.7, pp. 1011-1022, 2024, DOI:10.32604/biocell.2024.050120 - 03 July 2024

Abstract Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the neurons. They are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of neurons. As the global population ages rapidly, increased people are being diagnosed with neurodegenerative diseases. It has been established that the onset of Alzheimer’s disease (AD) is closely linked with increasing age and its major pathological features include amyloid-beta plaques (Aβ), Tau hyperphosphorylation, Neurofibrillary tangles (NFTs), neuronal death as well as synaptic loss. The involvement of microglia is crucial… More >

Jiaqiong Wang^1,2, Tao Yang¹, Chen Hu¹, Yu Zhang^3,*, Ling Zhou^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1203-1218, 2024, DOI:10.32604/fdmp.2023.045825 - 27 June 2024

Abstract To investigate the influence of structural parameters on the performances and internal flow characteristics of partial flow pumps at a low specific speed of 10000 rpm, special attention was paid to the first and second stage impeller guide vanes. Moreover, the impeller blade outlet width, impeller inlet diameter, blade inclination angle, and number of blades were considered for orthogonal tests. Accordingly, nine groups of design solutions were formed, and then used as a basis for the execution of numerical simulations (CFD) aimed at obtaining the efficiency values and heads for each design solution group. The More >