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  • Open Access

    ARTICLE

    A Time-Continuous Model for an Untreated HIV-Infection and a Novel Non-Standard Finite-Difference-Method for Its Discretization

    Benjamin Wacker1, Jan Christian Schlüter2,3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 2191-2229, 2025, DOI:10.32604/cmes.2025.067397 - 31 August 2025

    Abstract In this work, we re-investigate a classical mathematical model of untreated HIV infection suggested by Kirschner and introduce a novel non-standard finite-difference method for its numerical solution. As our first contribution, we establish non-negativity, boundedness of some solution components, existence globally in time, and uniqueness on a time interval for an arbitrary for the time-continuous problem which extends known results of Kirschner’s model in the literature. As our second analytical result, we establish different equilibrium states and examine their stability properties in the time-continuous setting or discuss some numerical tools to evaluate this question. Our More >

  • Open Access

    ARTICLE

    Comparative Analyses of Physiological and Transcriptomic Responses Reveal Chive (Allium ascalonicum L.) Bolting Tolerance Mechanisms

    Siyang Ou1, Liuyan Yang1, Tingting Yuan1, Mutong Li1, Guohui Liao2, Wanping Zhang1, Guangdong Geng1,*, Suqin Zhang1,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2441-2460, 2025, DOI:10.32604/phyton.2025.068368 - 29 August 2025

    Abstract Chive (Allium ascalonicum L.), a seeding-vernalization-type vegetable, is prone to bolting. To explore the physiological and molecular mechanisms of its bolting, bolting-prone (‘BA’) and bolting-resistant (‘WA’) chives were sampled at the vegetative growth, floral bud differentiation, and bud emergence stages. No bolting was observed in bolting-resistant ‘WA’ on the 130th day after planting, whereas the bolting reached 39.22% in bolting-prone ‘BA’, which was significantly higher than that of ‘WA’. The contents of gibberellins, abscisic acid, and zeatin riboside after floral bud differentiation in ‘WA’ were significantly less than in ‘BA’, whereas the indoleacetic acid content in… More >

  • Open Access

    ARTICLE

    Improved Cyclic System Based Optimization Algorithm (ICSBO)

    Yanjiao Wang, Zewei Nan*

    CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4709-4740, 2025, DOI:10.32604/cmc.2025.058894 - 06 March 2025

    Abstract Cyclic-system-based optimization (CSBO) is an innovative metaheuristic algorithm (MHA) that draws inspiration from the workings of the human blood circulatory system. However, CSBO still faces challenges in solving complex optimization problems, including limited convergence speed and a propensity to get trapped in local optima. To improve the performance of CSBO further, this paper proposes improved cyclic-system-based optimization (ICSBO). First, in venous blood circulation, an adaptive parameter that changes with evolution is introduced to improve the balance between convergence and diversity in this stage and enhance the exploration of search space. Second, the simplex method strategy… More >

  • Open Access

    ARTICLE

    Global Piecewise Analysis of HIV Model with Bi-Infectious Categories under Ordinary Derivative and Non-Singular Operator with Neural Network Approach

    Ghaliah Alhamzi1, Badr Saad T. Alkahtani2, Ravi Shanker Dubey3, Mati ur Rahman4,5,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.1, pp. 609-633, 2025, DOI:10.32604/cmes.2024.056604 - 17 December 2024

    Abstract This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu (AB) derivatives having arbitrary order. The HIV infection model has a susceptible class, a recovered class, along with a case of infection divided into three sub-different levels or categories and the recovered class. The total time interval is converted into two, which are further investigated for ordinary and fractional order operators of the AB derivative, respectively. The proposed model is tested separately for unique solutions and existence on… More >

  • Open Access

    ARTICLE

    A Collocation Technique via Pell-Lucas Polynomials to Solve Fractional Differential Equation Model for HIV/AIDS with Treatment Compartment

    Gamze Yıldırım1,2, Şuayip Yüzbaşı3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.1, pp. 281-310, 2024, DOI:10.32604/cmes.2024.052181 - 20 August 2024

    Abstract In this study, a numerical method based on the Pell-Lucas polynomials (PLPs) is developed to solve the fractional order HIV/AIDS epidemic model with a treatment compartment. The HIV/AIDS mathematical model with a treatment compartment is divided into five classes, namely, susceptible patients (S), HIV-positive individuals (I), individuals with full-blown AIDS but not receiving ARV treatment (A), individuals being treated (T), and individuals who have changed their sexual habits sufficiently (R). According to the method, by utilizing the PLPs and the collocation points, we convert the fractional order HIV/AIDS epidemic model with a treatment compartment into… More >

  • Open Access

    ARTICLE

    Comparative Analysis of Reaction to Fire and Flammability of Hemp Shives Insulation Boards with Incorporated Microencapsulated Phase Change Materials

    Inga Zotova1,*, Edgars Kirilovs1, Laura Ziemele2

    Journal of Renewable Materials, Vol.12, No.3, pp. 603-613, 2024, DOI:10.32604/jrm.2024.047607 - 11 April 2024

    Abstract Nowadays buildings contain innovative materials, materials from local resources, production surpluses and rapidly renewable natural resources. Phase Change Materials (PCM) are one such group of novel materials which reduce building energy consumption. With the wider availability of microencapsulated PCM, there is an opportunity to develop a new type of insulating materials, combinate PCM with traditional insulation materials for latent heat energy storage. These materials are typically flammable and are located on the interior wall finishing yet there has been no detailed assessment of their fire performance. In this research work prototypes of low-density insulating boards… More > Graphic Abstract

    Comparative Analysis of Reaction to Fire and Flammability of Hemp Shives Insulation Boards with Incorporated Microencapsulated Phase Change Materials

  • Open Access

    ARTICLE

    Construction of a Computational Scheme for the Fuzzy HIV/AIDS Epidemic Model with a Nonlinear Saturated Incidence Rate

    Muhammad Shoaib Arif1,2,*, Kamaleldin Abodayeh1, Yasir Nawaz2

    CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.2, pp. 1405-1425, 2024, DOI:10.32604/cmes.2023.028946 - 17 November 2023

    Abstract This work aimed to construct an epidemic model with fuzzy parameters. Since the classical epidemic model does not elaborate on the successful interaction of susceptible and infective people, the constructed fuzzy epidemic model discusses the more detailed versions of the interactions between infective and susceptible people. The next-generation matrix approach is employed to find the reproduction number of a deterministic model. The sensitivity analysis and local stability analysis of the system are also provided. For solving the fuzzy epidemic model, a numerical scheme is constructed which consists of three time levels. The numerical scheme has More >

  • Open Access

    ARTICLE

    EduASAC: A Blockchain-Based Education Archive Sharing and Access Control System

    Ronglei Hu1, Chuce He1, Yaping Chi2, Xiaoyi Duan1, Xiaohong Fan1, Ping Xu1, Wenbin Gao1,*

    CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3387-3422, 2023, DOI:10.32604/cmc.2023.042000 - 26 December 2023

    Abstract In the education archive sharing system, when performing homomorphic ciphertext retrieval on the storage server, there are problems such as low security of shared data, confusing parameter management, and weak access control. This paper proposes an Education Archives Sharing and Access Control (EduASAC) system to solve these problems. The system research goal is to realize the sharing of security parameters, the execution of access control, and the recording of system behaviors based on the blockchain network, ensuring the legitimacy of shared membership and the security of education archives. At the same time, the system can… More >

  • Open Access

    REVIEW

    Exosomes in viral infection: Effects for pathogenesis and treatment strategies

    FATEMEH HEIDARI1,2, REIHANEH SEYEDEBRAHIMI1,2, PIAO YANG3, MOHSEN ESLAMI FARSANI1,2, SHIMA ABABZADEH2,4, NASER KALHOR5, HAMED MANOOCHEHRI6, MOHSEN SHEYKHHASAN7,*, MARYAM AZIMZADEH8,9,*

    BIOCELL, Vol.47, No.12, pp. 2597-2608, 2023, DOI:10.32604/biocell.2023.043351 - 27 December 2023

    Abstract Exosomes are small vesicles that carry molecules from one cell to another. They have many features that make them interesting for research, such as their stability, low immunogenicity, size of the nanoscale, toxicity, and selective delivery. Exosomes can also interact with viruses in diverse ways. Emerging research highlights the significant role of exosomes in viral infections, particularly in the context of diseases like COVID-19, HIV, HBV and HCV. Understanding the intricate interplay between exosomes and the human immune system holds great promise for the development of effective antiviral therapies. An important aspect is gaining clarity More >

  • Open Access

    ARTICLE

    Research on Multi-Blockchain Electronic Archives Sharing Model

    Fang Yu1, Wenbin Bi2, Ning Cao3,*, Jun Luo4, Diantang An5, Liqiang Ding4, Russell Higgs6

    CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3921-3931, 2023, DOI:10.32604/cmc.2023.028330 - 08 October 2023

    Abstract The purpose of introducing blockchain into electronic archives sharing and utilization is to break the information barrier between electronic archives sharing departments by relying on technologies such as smart contract and asymmetric encryption. Aiming at the problem of dynamic permission management in common access control methods, a new access control method based on smart contract under blockchain is proposed, which improves the intelligence level under blockchain technology. Firstly, the Internet attribute access control model based on smart contract is established. For the dynamic access of heterogeneous devices, the management contract, permission judgment contract and access… More >

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