DIMITRA P. VAGELI^1,2,*, PANAGIOTIS G. DOUKAS³, KERASIA GOUPOU², ANTONIOS D. BENOS², KYRIAKI ASTARA^2,4, KONSTANTINA ZACHAROULI², SOTIRIS SOTIRIOU⁵, MARIA IOANNOU²

Oncology Research, Vol.32, No.8, pp. 1239-1256, 2024, DOI:10.32604/or.2024.052130

Abstract Glioblastoma multiforme (GBM) is an aggressive primary brain tumor characterized by extensive heterogeneity and vascular proliferation. Hypoxic conditions in the tissue microenvironment are considered a pivotal player leading tumor progression. Specifically, hypoxia is known to activate inducible factors, such as hypoxia-inducible factor 1alpha (HIF-1α), which in turn can stimulate tumor neo-angiogenesis through activation of various downward mediators, such as the vascular endothelial growth factor (VEGF). Here, we aimed to explore the role of HIF-1α/VEGF immunophenotypes alone and in combination with other prognostic markers or clinical and image analysis data, as potential biomarkers of GBM prognosis… More >

Qianren Xiao^*1, Lu Huang^†1, Zhongzu Zhang^‡1, Xiang Chen^*, Jiaquan Luo^*, Zhanmin Zhang^§, Shaoqing Chen^§, Yong Shu^*, Zhimin Han^*, Kai Cao^*

Oncology Research, Vol.25, No.2, pp. 267-275, 2017, DOI:10.3727/096504016X14732510786564

Abstract miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-140 in 40 paired OS tissues. Restoring miR-140 expression in OS cells had a marked effect on inhibiting cell proliferation and invasion, inducing cell apoptosis in vitro, and suppressing tumor growth in vivo. Moreover, a bioinformatics prediction indicated that the histone deacetylase 4 (HDAC4) is a target gene of miR-140 and More >

Xinlu Liu, Xiaodong Tan, Peng Liu, Yunhao Wu, Songying Qian, Xiaobo Zhang

Oncology Research, Vol.26, No.7, pp. 1123-1131, 2018, DOI:10.3727/096504018X15166223632406

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors known, with an overall 5-year survival rate of less than 6% due to early local invasion and distant metastasis. Exploring suitable therapeutic targets associated with invasion and metastasis is required for improving the prognosis of PDAC. In this study, we investigated the role of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) in PDAC. PGAM1 expression was examined in tissue samples of 54 PDAC patients using immunohistochemistry, and the correlation between clinicopathological expression and PGAM1 expression was determined. A survival curve was generated using the… More >

Lixia Jiang^*1, Shaohua Shi^†1, Qiaofa Shi^‡, Huijuan Zhang^*, Yu Xia^§, Tianyu Zhong^*

Oncology Research, Vol.26, No.7, pp. 1055-1062, 2018, DOI:10.3727/096504018X15152056890500

Abstract HIF-2α knockdown inhibits proliferation, arrests the cell cycle, and promotes apoptosis and autophagy under hypoxic conditions in cervical cancer. However, the upstream regulatory mechanism of HIF-2α expression is unclear. MicroRNAs (miRNAs) degrade target mRNAs by binding to the 3'-untranslated region of mRNAs. In this study, we investigated the role of miRNAs in the regulation of HIF-2α expression in cervical cancer under hypoxic conditions. miRNAs regulating HIF-2α expression were predicted using TargetScan and miRanda and were determined in cervical cancer under hypoxic conditions by qRT-PCR. Additionally, the targeted regulation of HIF-2α by miR-519d-3p was evaluated by… More >

ALEKSANDRA GORNOSTAEVA, LUDMILA BURAVKOVA, MARGARITA LOBANOVA, ELENA ANDREEVA^*

BIOCELL, Vol.48, No.5, pp. 677-692, 2024, DOI:10.32604/biocell.2024.048873

Abstract The structural and associated molecules of the extracellular matrix (ECM) complex is an important component of the local milieu of cells, both for maintaining their functions and homeostasis. It is a dynamic structure that is finely tuned to changes in the microenvironment. One of these factors is hypoxia, which can arise in tissues due to physiological or pathological effects. As a result of the hypoxic effect, the properties of the ECM are significantly modified, stiffness increases, the balance between degradation and synthesis of structural proteins shifts, and the deposition of biologically active mediators’ changes. Hypoxia-inducible… More >

Tianshu Wei¹, Jinjie Huang^1,2,*

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1599-1612, 2024, DOI:10.32604/cmc.2024.048098

Abstract Zero-shot learning enables the recognition of new class samples by migrating models learned from semantic features and existing sample features to things that have never been seen before. The problems of consistency of different types of features and domain shift problems are two of the critical issues in zero-shot learning. To address both of these issues, this paper proposes a new modeling structure. The traditional approach mapped semantic features and visual features into the same feature space; based on this, a dual discriminator approach is used in the proposed model. This dual discriminator approach can… More >

YIWEN ZHU¹, LIU YANG¹, YING YU¹, YING XIONG², PING XIAO², XIAO FU², XIN LUO^2,*

Oncology Research, Vol.32, No.5, pp. 899-910, 2024, DOI:10.32604/or.2023.042604

Abstract Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis. Since there is no permanent therapy for this condition, it is necessary to develop a cure. Therefore, this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A (HYSA) in osteosarcoma cell lines (MG63). In this investigational study, MG63 cells were utilized. Microarray experiments, quantitative polymerase chain reaction (qPCR), immunofluorescent staining, extracellular acidification rate (ECAR), oxygen consumption rate (OCR), glucose consumption, lactate production, and ATP levels, proliferation assay, 5-Ethynyl-2′-deoxyuridine (EDU) staining, and Western… More >

RAFAT SABA^*, MOHD. KASHIF AZIZ, GHULAM MUSTAFA, ARPIT SRIVASTAVA, SHEKHAR SRIVASTAVA^*

Journal of Polymer Materials, Vol.38, No.1-2, pp. 153-166, 2021, DOI:10.32381/JPM.2021.38.1-2.12

Abstract We have synthesized Schiff’s base of Fe₃ O₄ @chitosan with 4,4'-diselenobisbenzaldehyde (Fe₃O₄ @CSSe) composite and used it as acatalyst for the oxidation of sulfides, having some advantageous properties such as eco-friendly, cost-effective and highly efficient magnetic biocatalyst of selenium. The synthesized schiff’s base was characterized by different physical characterization techniques such as Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Vibrating sample magnetometer (VSM)and Dynamic light scattering (DLS). Further, we used the resulting schiff’s base as a catalyst in the presence of a green oxidant (H₂ O₂ ) to oxidize sulfides to corresponding sulfoxides at room temperature. It More >

Haomiao Wang¹, Jinxi Wang², Qingmei Sui^2,*, Faye Zhang², Yibin Li¹, Mingshun Jiang², Phanasindh Paitekul³

Structural Durability & Health Monitoring, Vol.18, No.2, pp. 91-110, 2024, DOI:10.32604/sdhm.2023.041522

Abstract Due to their robust learning and expression ability for complex features, the deep learning (DL) model plays a vital role in bearing fault diagnosis. However, since there are fewer labeled samples in fault diagnosis, the depth of DL models in fault diagnosis is generally shallower than that of DL models in other fields, which limits the diagnostic performance. To solve this problem, a novel transfer residual Swin Transformer (RST) is proposed for rolling bearings in this paper. RST has 24 residual self-attention layers, which use the hierarchical design and the shifted window-based residual self-attention. Combined More >

Wenjie Li¹, Yucheng Gao², Guoqing Liu², Rongkai Hao², Meijie Zhang², Xiaotian Li^1,*

International Journal of Mental Health Promotion, Vol.26, No.2, pp. 83-92, 2024, DOI:10.32604/ijmhp.2023.042014

Abstract As adolescent mental health problems are becoming a more serious issue globally, this paper explores the relationship of physical activity in adolescents and its frequency on mental health as well as examines the mediating effects of life satisfaction and self-rated health in order to provide a reference for the promotion of mental health in adolescents. A sample of 3578 Chinese high school students completed questionnaires assessing their mental health, physical activity frequency, life satisfaction, and self-rated health. The mean SCL-90 value for adolescents was found to be 1.629%, and 24.73% of adolescents had varying degrees… More >