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    ARTICLE

    Preparation and Sustained Release of 2-Hydroxyethyl Methacrylate -N-Vinyl-2-Pyrrolidone Hydrogel for Ophthalmic Drug

    Xiaojuan He1, Chanyuan Li1, Shaokang Wang1, Jingyi Zhu1, Yabin Zhang1,*, Zhen Guo2, Lihua Wu3,*

    Journal of Polymer Materials, Vol.41, No.4, pp. 263-279, 2024, DOI:10.32604/jpm.2024.055821 - 16 December 2024

    Abstract Eye drops are the usual method to treat eye diseases, and gel polymer provides the carrier which could be used for ophthalmic drug delivery. However, the stable and sustained release is the main issue for the ophthalmic drug and is concerned by many researchers. In this study, composite hydrogels were prepared using 2-hydroxyethyl methacrylate (HEMA), and N-vinyl-2-pyrrolidone (NVP) used for ophthalmic drug loading and release. According to the results of Fourier transform infrared spectroscopy (FTIR), the disappearance of the C=C bond in hydrogel indicated that the copolymerization reaction between HEMA and NVP was successful. The… More > Graphic Abstract

    Preparation and Sustained Release of 2-Hydroxyethyl Methacrylate -N-Vinyl-2-Pyrrolidone Hydrogel for Ophthalmic Drug

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