EGOR V. BATOROV^1,2,*, ALISA D. INESHINA², TATIANA A. ARISTOVA³, VERA V. DENISOVA³, SVETLANA A. SIZIKOVA³, DARIA S. BATOROVA³, GALINA Y. USHAKOVA³, EKATERINA Y. SHEVELA¹, ELENA R. CHERNYKH¹

Oncology Research, Vol.32, No.10, pp. 1575-1587, 2024, DOI:10.32604/or.2024.047893 - 18 September 2024

Abstract Background: Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma (MM) progression. Simultaneously, previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with common γ-chain family cytokines in vitro and during homeostatic proliferation. The aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets up-regulating PD-1 and TIM-3 checkpoint molecules. Methods: The expression of CD25, CD122, CD127 common γ-chain cytokine receptors, phosphorylated signal transducer and activator of transcription-5 (pSTAT5) and eomesodermin (EOMES) was comparatively assessed with flow… More >

MINGYUE HUANG^1,#, JUNFEI DAI^1,#, XIANLIANG ZHONG², JIN WANG², JIANZHONG XU², BO DU^2,*

BIOCELL, Vol.48, No.6, pp. 889-896, 2024, DOI:10.32604/biocell.2024.050097 - 10 June 2024

Abstract Chronic subdural hematoma (CSDH) is a disease characterized by capsuled blood products that progressively occupy the intracranial space, causing intracranial hypertension and compression in the brain. CSDH frequently occurs in all demographics, especially in the elderly, but the pathogenesis of CSDH remains unclear. In this review, we discuss the origin, development, and current treatment strategies of CSDH. For the first time, we analyzed the cellular and molecular compositions of hematoma membranes with a focus on neomembrane formation, a complex early-stage interactive event in hematoma pathogenesis. We hypothesize that in patients with CSDH, dural border cells… More >

ZHIGANG XIA^1,#, MENGYAO TIAN^1,#, YUCAI CHENG¹, WENFANG YI¹, ZEFAN DU^1,2, TIANWEN LI^1,2, YUCHEN WEN¹, LINDI LI^1,2, YONG LIU^1,2,*, CHUN CHEN^1,*

Oncology Research, Vol.32, No.6, pp. 1109-1118, 2024, DOI:10.32604/or.2024.049792 - 23 May 2024

Abstract Background: Chimeric antigen receptor T (CAR-T) cell therapy has achieved marked therapeutic success in ameliorating hematological malignancies. However, there is an extant void in the clinical guidelines concerning the most effective chemotherapy regimen prior to chimeric antigen receptor T (CAR-T) cell therapy, as well as the optimal timing for CAR-T cell infusion post-chemotherapy. Materials and Methods: We employed cell-derived tumor xenograft (CDX) murine models to delineate the optimal pre-conditioning chemotherapy regimen and timing for CAR-T cell treatment. Furthermore, transcriptome sequencing was implemented to identify the therapeutic targets and elucidate the underlying mechanisms governing the treatment regimen.… More >

Victoire Vigneron^1,2,*, Eugénie Gosset Grainville¹

Psycho-Oncologie, Vol.18, No.1, pp. 43-48, 2024, DOI:10.32604/po.2023.043095 - 25 March 2024

Abstract Cet article illustre la pratique clinique en psycho-oncologie, au sein d’un service d’onco-hématologie pédiatrique par de jeunes psychologues. Pour commencer, nous aborderons la place du psychologue dans un service somatique. La créativité dans le travail clinique et la modulation de temporalité médicale. Il s’agit ici de discuter la construction de l’identité professionnelle en lien avec la construction de l’alliance thérapeutique avec les patients. Spécifiquement nous aborderons le rapport à la créativité, nécessaire pour accompagner des enfants et adolescents dans leurs questionnements existentiels. Ce travail de créativité dans l’alliance thérapeutique, sera illustré à l’aide de deux More >

Wenyuan Chen¹, Tao Zhang², Yantao Yang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09754

Abstract Based on the moving-least-squares immersed boundary method, we proposed a new technique to improve the calculation of the volume force representing the body boundary. For boundary with simple geometry, we theoretically analyze the error between the desired volume force at boundary and the actual force applied by the original method. The ratio between the two forces is very close to a constant and exhibits a very narrow distribution. A spatially uniform coefficient is then introduced to correct the force and can be fixed by the least-square method over all boundary markers. Such method is explicit… More >

P. Sabitha^*, G. Meeragandhi

Intelligent Automation & Soft Computing, Vol.37, No.2, pp. 1983-2000, 2023, DOI:10.32604/iasc.2023.034402 - 21 June 2023

Abstract Developing an automatic and credible diagnostic system to analyze the type, stage, and level of the liver cancer from Hematoxylin and Eosin (H&E) images is a very challenging and time-consuming endeavor, even for experienced pathologists, due to the non-uniform illumination and artifacts. Albeit several Machine Learning (ML) and Deep Learning (DL) approaches are employed to increase the performance of automatic liver cancer diagnostic systems, the classification accuracy of these systems still needs significant improvement to satisfy the real-time requirement of the diagnostic situations. In this work, we present a new Ensemble Classifier (hereafter called ECNet)… More >

Yuan Hu¹, Xiaohui Yang², Jie Dong³, Peng Huang², Jinwen Luo², Guangxian Yang², James D. St. Louis⁴, Xicheng Deng^2,*

Congenital Heart Disease, Vol.17, No.6, pp. 687-695, 2022, DOI:10.32604/chd.2022.024333 - 11 October 2022

Abstract Background: Interventricular septal hematoma is a rare complication after congenital cardiac repair. The management varies according to the literature. We present our experience with this rare complication. Methods: Echocardiography database were reviewed with the term ‘‘hematoma’’ or “hypoechoic mass” for patients who underwent congenital heart surgery from January 2018 to December 2021 at our institution to identify potential interventricular septal hematoma cases. Relevant data of the patients identified were collected. Focus was put on the presentation, management, outcomes according to patent medical charts and serial echocardiographic report data. Results: In total, there were 5 patients included. The… More > Graphic Abstract

Giuseppe Emmanuele Umana^1,*, Gianluca Ferini², Antonio Crea¹, Bipin Chaurasia³, Vishal Chavda⁴, Leonardo Corbino¹, Daniele Franceschini¹, Maria Grazia Tranchina⁵, Marco Fricia¹, Francesca Graziano⁶, Giovanni Federico Nicoletti⁶, Salvatore Cicero¹, Gianluca Scalia⁶

Oncologie, Vol.24, No.2, pp. 341-348, 2022, DOI:10.32604/oncologie.2022.021347 - 29 June 2022

Abstract Concomitant acute epidural hematoma (EDH) and subdural hematoma (SDH) is a rare finding, and its bilateral onset has not yet been reported in literature. We present the first report of a patient affected by post-traumatic concomitant EDH and SDH, with the contralateral, delayed onset of another, associated with meningioma previously treated with gamma knife. A 60-year-old female patient with a history of simple focal seizures with motor symptoms and well-controlled by drugs since childhood, arterial hypertension, and incidental diagnosis of multiple meningiomas was referred to our department after falling down the stairs. Initially, the patient… More >

LIANGYING ZHANG¹, SHAOTING ZHANG¹, ZHAOYANG FAN¹, ZONGYING JIANG^1,2, ANBU LIU¹, SHUJING LI^1,2, JIANMIN SUN^1,*

BIOCELL, Vol.46, No.9, pp. 2081-2087, 2022, DOI:10.32604/biocell.2022.020109 - 18 May 2022

Abstract PI3 kinases are important for KIT signaling and KIT mutants mediated cell transformation. In order to know the difference of PI3 kinase isoforms p110α and p110δ in the signaling of wild-type KIT and the often occurred KIT mutation D816V in hematopoietic malignancy mastocytosis, the predominant PI3 kinase isoform p110δ in hematopoietic tissues was knocked out in hematopoietic cells. We found that loss of p110δ expression dramatically inhibits PI3 kinase activation mediated by both wild-type KIT and KIT/D816V. By over expression of p110α in p110δ knock out cells, wild-type KIT mediated PI3 kinase activation was not More >

XIANLIANG HOU^1,2,3,#, DONGE TANG^1,#, FENGPING ZHENG^1,#, MINGLIN OU³, YONG XU¹, HUIXUAN XU¹, XIAOPING HONG⁴, XINZHOU ZHANG¹, WEIER DAI⁵, DONGZHOU LIU^4,*, YONG DAI^1,*

BIOCELL, Vol.44, No.4, pp. 559-582, 2020, DOI:10.32604/biocell.2020.011022 - 24 December 2020

Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by abnormal cellular and humoral immune responses and excessive autoantibody production. The precise pathologic mechanism of SLE remains elusive. The advent of single-cell RNA sequencing (scRNA-seq) enables unbiased analysis of the molecular differences of cell populations at the single-cell level. We used scRNA-seq to profile the transcriptomes of peripheral blood mononuclear cells from an SLE patient compared with a healthy control (HC). A total of 16,021 cells were analyzed and partitioned into 12 distinct clusters. The marker genes of each cluster and the four major… More >