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Search Results (6)
  • Open Access

    REVIEW

    Mitochondrial-epigenetic crosstalk as an integrative standpoint into gut microbiome dysbiosis and related diseases

    VINíCIUS AUGUSTO SIMãO1, LUIZ GUSTAVO DE ALMEIDA CHUFFA1, LEóN FERDER2, FELIPE INSERRA2, WALTER MANUCHA3,4,*

    BIOCELL, Vol.48, No.10, pp. 1429-1442, 2024, DOI:10.32604/biocell.2024.053478 - 02 October 2024

    Abstract The interplay between mitochondria, epigenetics, and the microbiota is intricately linked to both health and disease. Within our cells, a complex molecular dance occurs, where these components intertwine in a mesmerizing ballet that plays a decisive role in our health. Mitochondria, beyond being energy powerhouses, modulate nuclear gene expression through messengers like reactive oxidative stress (ROS) and calcium. Epigenetics, acting as the molecular conductor, regulates the expression of both nuclear and mitochondrial genes through modifications like DNA methylation. The intestinal microbiota itself produces short-chain fatty acids (SCFAs) that influence mitochondrial activity. SCFA-induced epigenetic modifications, like… More >

  • Open Access

    REVIEW

    Modulatory role of plant-derived metabolites on host-microbiota interactions: personalized therapeutics outlook

    POOJA YADAV, NAR SINGH CHAUHAN*

    BIOCELL, Vol.48, No.8, pp. 1127-1143, 2024, DOI:10.32604/biocell.2024.051318 - 02 August 2024

    Abstract A diverse array of microbes in and on the human body constitute the microbiota. These micro-residents continuously interact with the human host through the language of metabolites to dictate the host’s physiology in health and illnesses. Any biotic and abiotic component ensuring a balanced host-microbiota interaction are potential microbiome therapeutic agents to overcome human diseases. Plant metabolites are continually being used to treat various illnesses. These metabolites target the host’s metabolic machinery and host-gut microbiota interactions to overcome human diseases. Despite the paramount therapeutic significance of the factors affecting host-microbiota interactions, a comprehensive overview of More > Graphic Abstract

    Modulatory role of plant-derived metabolites on host-microbiota interactions: personalized therapeutics outlook

  • Open Access

    REVIEW

    Does young feces make the elderly live better? Application of fecal microbiota transplantation in healthy aging

    YUANYUAN LIAO1,2,3, XINSI LI2,3, QIAN LI2,3, YIZHONG WANG4, XIUJUN TAN1,2,3, TING GONG2,3,5,*

    BIOCELL, Vol.48, No.6, pp. 873-887, 2024, DOI:10.32604/biocell.2024.050324 - 10 June 2024

    Abstract As we are facing an aging society, anti-aging strategies have been pursued to reduce the negative impacts of aging and increase the health span of human beings. Gut microbiota has become a key factor in the anti-aging process. Modulation of gut microbiota by fecal microbiota transplantation (FMT) to prevent frailty and unhealthy aging has been a hot topic of research. This narrative review summarizes the benefits of FMT for health span and lifespan, brains, eyes, productive systems, bones, and others. The mechanisms of FMT in improving healthy aging are discussed. The increased beneficial bacteria and More >

  • Open Access

    REVIEW

    How aging affects bone health via the intestinal micro-environment

    HUAN HU1,2,*, YUE HUANG1, FANGZHOU LIU1, QIAN WANG1,2, YANZI YAO3,*

    BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311 - 15 March 2024

    Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes More >

  • Open Access

    REVIEW

    Potential roles of functional bacterial amyloid proteins, bacterial biosurfactants and other putative gut microbiota products in the etiopathogeny of Parkinson’s Disease

    EMILIA MANOLE1,2,#, LAURA DUMITRESCU2,3,#, CRISTINA NICULIȚE1,3, BOGDAN OVIDIU POPESCU1,2,3, LAURA CRISTINA CEAFALAN1,3,*

    BIOCELL, Vol.45, No.1, pp. 1-16, 2021, DOI:10.32604/biocell.2021.013452 - 26 January 2021

    Abstract An increasing number of studies provide evidence for the existence of a microbiota-gut-brain axis and its potential involvement in the development of sporadic Parkinson’s disease and other neurodegenerative conditions. The neuropathologic hallmark of Parkinson’s disease is the presence of brain intraneuronal aggregates of misfolded alpha-synuclein, known as Lewy bodies. Some gut microbiota products may trigger alpha-synuclein conformational changes in the neurons of the enteric nervous system, which can then spread to the brain in a prion-like fashion through the vagus nerve. Others may interfere with neuroinflammatory pathways and susceptibility to neurodegeneration. In this review, we More >

  • Open Access

    ARTICLE

    Elemental sulfur upregulated testicular testosterone biosynthesis by associating with altered gut microbiota in mice

    YUAN BI1,2,#, TIANQI LI2,#, HONGJIE PAN2, MING GUO2, LIANGKANG CHEN2, QI QI1, MEIXIN ZHANG2, LINGLING ZHANG2, LININ YU2, XIAOFENG WAN2, HUAJUN ZHENG2,*, RUNSHENG LI2,*

    BIOCELL, Vol.44, No.3, pp. 301-313, 2020, DOI:10.32604/biocell.2020.011208 - 22 September 2020

    Abstract Elemental sulfur has been used as a traditional Chinese medicine to treat the late-onset hypogonadism and impotence without a clarified mechanism for many hundreds of years. In the present study, mice were received sulfur or distilled water for 35 days by daily intragastric gavage at a dose of 250 mg/kg body weight. Then, the serum testosterone level and genes associated with testicular testosterone biosynthesis (TTB) were detected. The gut microbiota was also analyzed by 16S rRNA gene sequencing. Serum testosterone level was significantly increased by 291.1% in sulfur-treated mice. The H2S levels in serum and feces… More >

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