Chong Wang^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.1, pp. 1-1, 2025, DOI:10.32604/icces.2025.012164

Abstract Please Creating mechanically robust tissue engineering scaffolds capable of delivering growth factors and stem cells in situ for hard tissue repair remains a significant challenge. Inspired by the spiral structure of ice cream, our group developed an advanced 3D printing technique known as cryogenic 3D printing to fabricate polyester-based scaffolds with embedded growth factors. This method utilizes water-in-oil (w/o) polyester emulsions containing growth factors as the printing ink, which is patterned onto a cryogenic substrate. The resulting scaffolds feature a hierarchically porous structure, allowing mesenchymal stem cells (MSCs) to easily attach and proliferate. Additionally, the… More >

Chen Liu, Xiaomeng Liu, Hongyuan Zhou, Wei Zhang, Tianqiang Song

European Cytokine Network, Vol.34, No.4, pp. 38-45, 2023, DOI:10.1684/ecn.2023.0483

Abstract The regenerative ability of the liver is essential for maintaining physiological functions and the injury repair process. The biological mechanisms that regulate liver regeneration remain poorly defined. These mechanisms are notable issues in clinical practice that affect the treatment of hepatic loss caused by hepatectomy, hepatic poisoning, or chronic viral infection. Increasing evidence shows that numerous growth factors, cytokines, and metabolic pathways influence the liver regenerative process. Of particular importance are cytokines and growth factors, which affect different stages of liver regeneration. In this review, we summarize the results obtained from studies that focused on More >

BIN ZHANG^1,#, JIANYI ZHAO^3,#, YONGZHI WANG^2,#, HUA XU¹, BO GAO¹, GUANGNING ZHANG¹, BIN HAN¹, GUOHONG SONG¹, JUNCHEN ZHANG^1,*, WEI MENG^1,*

Oncology Research, Vol.31, No.6, pp. 917-927, 2023, DOI:10.32604/or.2023.030425 - 15 September 2023

Abstract Glioblastoma (GBM) is the most aggressive cancer of the brain and has a high mortality rate due to the lack of effective treatment strategy. Clarification of molecular mechanisms of GBM’s characteristic invasive growth are urgently needed to improve the poor prognosis. Single-nuclear sequencing of primary and recurrent GBM samples revealed that levels of M3 muscarinic acetylcholine receptor (CHRM3) were significantly higher in the recurrent samples than in the primary samples. Moreover, immunohistochemical staining of an array of GBM samples showed that high levels of CHRM3 correlated with poor prognosis, consistent with The Cancer Genome Atlas More >

ALEKSANDRA GORNOSTAEVA, ELENA ANDREEVA^*, LUDMILA BURAVKOVA^*

BIOCELL, Vol.46, No.9, pp. 2049-2052, 2022, DOI:10.32604/biocell.2022.019993 - 18 May 2022

Abstract Multipotent mesenchymal stromal cells (MSCs) are actively involved in reparation and inflammation processes, providing damaged tissue reparation and suppressing immune cell responses in vivo. The effects are mostly due to the production of a wide range of paracrine factors, including growth factors and immunomodulatory mediators. To induce immunosuppressive activity, MSCs are primed by inflammatory cytokines, which results in an increased production of immunomodulatory molecules. However, stimulation of reparative properties is also necessary. This viewpoint manuscript highlights the possibilities of inflammatory priming to increase the production of growth factors by MSCs. More >

EJLAL ABU-EL-RUB^1,2,*, RAMADA R. KHASAWNEH¹, FATIMAH A. ALMAHASNEH¹, HANA M. ZEGALLAI^3,4

BIOCELL, Vol.46, No.4, pp. 907-911, 2022, DOI:10.32604/biocell.2022.018306 - 15 December 2021

Abstract The paracrine and immunomodulatory cytokines secreted by mesenchymal stem cells (MSCs), generally referred to as the MSCs derived secretome, has substantial potential for the treatment of many chronic and degenerative diseases. MSCs secretome contains both common and disease specific cytokines and modulators that can be beneficial against a wide range of chronic diseases. Herein, we discuss the MSCs secretome composition profile and its translational applicability and the challenges surrounding its use in clinical settings. More >

Virginia Aragon Sanabria¹, Cheng Dong^*

Molecular & Cellular Biomechanics, Vol.15, No.1, pp. 1-19, 2018, DOI:10.3970/mcb.2018.015.001

Abstract Endothelial barrier function is critical for tissue homeostasis throughout the body. Disruption of the endothelial monolayer leads to edema, vascular diseases and even cancer metastasis among other pathological conditions. Breakdown of the endothelial barrier integrity triggered by cytokines (e.g.IL-8,IL-1β) and growth factors (e.g.VEGF) is well documented. However, endothelial cells are subject to major biomechanical forces that affect their behavior. Due to their unique location at the interface between circulating blood and surrounding tissues, endothelial cells experience shear stress, strain and contraction forces. More than three decades ago, it was already appreciated that shear flow caused More >

Francesca Capone¹, Susan Costantini¹, Eliana Guerriero¹, Rosa Calemma², Maria Napolitano², Stefania Scala², Francesco Izzo², Giuseppe Castello^1,2

European Cytokine Network, Vol.21, No.2, pp. 99-104, 2010, DOI:10.1684/ecn.2010.0192

Abstract The role played by the microenvironment in cancer induction, promotion and progression is crucial. Emerging evidence suggests that cytokines, chemokines and growth factors are major players in carci-nogenesis. Therefore, a detailed understanding of factors and mechanisms associated with the processes leading from inflammation to cancer could improve the therapeutic strategies against this disease. We have used hepatocarcinoma as our model in this study. We evaluated the serum levels of 50 different cytokines, chemo-kines and growth factors in patients affected by HCC with chronic HCV-related hepatitis and liver cirrhosis using multiplex biometric ELISA-based immunoassay. Our data More >

Susan Costantini¹, Francesca Capone¹, Eliana Guerriero¹, Patrizia Maio², Giovanni Colonna³, Giuseppe Castello¹

European Cytokine Network, Vol.21, No.4, pp. 251-256, 2010, DOI:10.1684/ecn.2010.0214

Abstract Hepatitis C virus (HCV) infection can present as an acute manifestation, and can lead to severecomplications such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). It represents a globalhealth problem because there is no vaccine currently available. Cytokines play an important role in viralclearance, infection control, inflammation, regeneration and fibrosis, and also are implicated in the pathologicalprocesses occurring in the liver during viral infection. Immunological markers of chronic HCV hepatitis pro-gression as compared to cirrhosis and HCC would be extremely useful, particularly for distinguishing betweenthe molecules produced during HCV-induced chronic inflammation and those secreted during… More >