Jeng-Shyang Pan^1,2, Wenda Li¹, Shu-Chuan Chu^1,*, Xiao Sui¹, Junzo Watada³

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 3033-3062, 2024, DOI:10.32604/cmc.2024.056310 - 18 November 2024

Abstract The growth optimizer (GO) is an innovative and robust metaheuristic optimization algorithm designed to simulate the learning and reflective processes experienced by individuals as they mature within the social environment. However, the original GO algorithm is constrained by two significant limitations: slow convergence and high memory requirements. This restricts its application to large-scale and complex problems. To address these problems, this paper proposes an innovative enhanced growth optimizer (eGO). In contrast to conventional population-based optimization algorithms, the eGO algorithm utilizes a probabilistic model, designated as the virtual population, which is capable of accurately replicating the… More >

Mohana Priya Govindarajan^*, Sangeetha Subramaniam Karuppaiya Bharathi

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2967-2986, 2024, DOI:10.32604/cmc.2024.055536 - 18 November 2024

Abstract In the present research, we describe a computer-aided detection (CAD) method aimed at automatic fetal head circumference (HC) measurement in 2D ultrasonography pictures during all trimesters of pregnancy. The HC might be utilized toward determining gestational age and tracking fetal development. This automated approach is particularly valuable in low-resource settings where access to trained sonographers is limited. The CAD system is divided into two steps: to begin, Haar-like characteristics were extracted from ultrasound pictures in order to train a classifier using random forests to find the fetal skull. We identified the HC using dynamic programming,… More >

CHAOQUN WANG¹, TING ZHANG², CHAOHE ZHANG^3,*

Oncology Research, Vol.32, No.12, pp. 1867-1879, 2024, DOI:10.32604/or.2024.044547 - 13 November 2024

Abstract Background: Drug resistance is the main factor contributing to cancer recurrence and poor prognosis. Exploration of drug resistance-related mechanisms and effective therapeutic targets are the aim of molecular targeted therapy. In our study, the role of long non-coding RNA (lncRNA) AFAP1-AS1 in gemcitabine resistance and related mechanisms were explored in cervical cancer cells. Methods: Gemcitabine-resistant cervical cancer cell lines HT-3-Gem and SW756-Gem were constructed using the gemcitabine concentration gradient method. The overall survival rates and recurrence-free survival rates were evaluated by Kaplan-Meier analysis. The interaction was verified through a Dual-luciferase reporter gene assay and a… More > Graphic Abstract

Lu Zhang^1,*, Yuzhuo Wang¹, Zhiwei Yu¹, Rong Jiang¹, Liguo Zhao¹, Yingdong Song^1,2

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-2, 2024, DOI:10.32604/icces.2024.012701

Abstract Thermo-mechanical fatigue (TMF), as the main failure mode of hot components of an aeroengine, are increasingly investigated recently [1,2]. TMF crack growth is studied in a nickel-based powder metallurgy (PM) superalloy subjected to in-phase (IP) and out-of-phase (OP), as well as isothermal fatigue (IF) at peak temperature. The crack growth rate and path are evaluated for both coarse grain (CG) and fine grain (FG) structure, especially the effects of phase angle and polycrystalline microstructure. The results show that the TMF crack propagation is mainly transgranular in OP condition; while in IP condition, crack propagates intergranularly… More >

Lixiang Wang¹, Longfei Wen^2,3, Rong Tian^2,3,*, Chun Feng^1,4,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-2, 2024, DOI:10.32604/icces.2024.011137

Abstract The extended finite element method (XFEM) has been successful in crack analysis but faces challenges in modeling multiple cracks. One challenge is the linear dependence and ill-conditioning of the global stiffness matrix, while another is the geometric description for multiple cracks. To address the first challenge, the Improved XFEM (IXFEM) [1–9] is extended to handle multiple crack problems, effectively eliminating issues of linear dependence and ill-conditioning. Additionally, to overcome the second challenge, a novel level set templated cover cutting method (LSTCCM) [10] is proposed, which combines the advantages of the level set method and cover More >

Hacer Kabakoğlue^1,2,*, Fatma Nuray Kuşçu Sahin²

International Journal of Mental Health Promotion, Vol.26, No.10, pp. 855-863, 2024, DOI:10.32604/ijmhp.2024.055653 - 31 October 2024

Abstract Background: Disasters have effects that leave great negative marks on our lives, even after many years have passed. Individuals who experience an earthquake experience physical and psychological difficulties. The purpose of this study is to determine how psychological resilience levels affect the feeling of hopelessness and post-traumatic growth in adults who experienced the 06 February, 2023 Turkey-Syria earthquake. Methods: Data were collected using the “Personal Information Form (PIF)”, “Turkish forms of Adult Resilience Measure (ARM)”, “Dispositional Hope Scale (DHS)” and “Post-Traumatic Growth Inventory (PTGI)”. In order to determine whether there is a significant difference in… More >

JINXIA CHEN^1,2,3,#, SULI DAI^1,2,#, GENG ZHANG^4,5, SISI WEI^1,2, XUETAO ZHAO³, YANG ZHENG^1,2, YAOJIE WANG^1,2, XIAOHAN WANG^1,2, YUNJIANG LIU^4,5,*, LIANMEI ZHAO^1,2,*

Oncology Research, Vol.32, No.11, pp. 1791-1802, 2024, DOI:10.32604/or.2024.049348 - 16 October 2024

Abstract Background: Triple-negative breast cancer (TNBC) is a heterogeneous, recurring cancer characterized by a high rate of metastasis, poor prognosis, and lack of efficient therapies. KBU2046, a small molecule inhibitor, can inhibit cell motility in malignant tumors, including breast cancer. However, the specific targets and the corresponding mechanism of its function remain unclear. Methods: In this study, we employed (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium) (MTS) assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in vitro. RNA-Seq was used to explore the targets of KBU2046 that inhibit the motility of TNBC.… More > Graphic Abstract

Yi Shi^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012366

Abstract The Nickel-based superalloy is wieldy applied in hot components of aero turbine engine due to its superior mechanical property at elevated temperature. However, the working condition of engine hot components are severe and thus the effect of high temperature, oxidation and time-dependent loading on fatigue crack growth behavior should be considered in structure analysis. In this study, first the effect of environment was experimentally investigated. Stand compact tension (CT) specimens under different temperatures and loading frequencies were tests to evaluate the role of temperature and time-dependent effect on fatigue crack growth. Results show that if… More >

Qiuyi Wang¹, Rong Yang¹, Bo Chen², Rui Bao^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.011878

Abstract Effects of hold time on the fatigue crack growth behavior in electron-beam powder-bed-fusion (PBF-EB) Inconel 718 alloy at 650 ∘C have been investigated in this study, with focuses on the anisotropic fatigue cracking resistance and fracture mechanism. The V-type specimen (which loading parallel to the columnar grain boundaries) gives better dwell-fatigue cracking resistance to the H-type specimen (which loading perpendicular to the columnar grain boundaries) due to its large deflections (nearly 90 °) on the crack path. These deflections are related to the change of crack growth mechanism. In both V-type and H-type specimens, when More >

Binchao Liu^1,2,*, Qiuyi Wang², Rui Bao²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.011835

Abstract With the everlasting pursuit for weight reduction, efforts are devoted to applying additively manufactured (AM) structures in aeronautic vehicles; however, anomalous fatigue crack growth (FCG) behaviors, such as deflection and branching, are recently observed in macroscale, which deviates from the predictions by classic fracture mechanics. In this work, FCG behaviors of direct energy deposited (DED) Ti–5Al–5Mo–5V–1Cr–1Fe (TC18 in China) are investigated, in which fatigue crack deflections induced by combined impacts of loading and microstructures are revealed. Experiment results show that cracks are more deflected in columnar grains due to the preferred distribution of acicular a… More >