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  • Open Access

    ARTICLE

    Differential Expression of Genes Related to Fruit Development and Capsaicinoids Synthesis in Habanero Pepper Plants Grown in Contrasting Soil Types

    Eduardo Burgos-Valencia1,#, Federico García-Laynes1,#, Ileana Echevarría-Machado1, Fatima Medina-Lara1, Miriam Monforte-González1, José Narváez-Zapata2,*, Manuel Martínez-Estévez1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 151-183, 2024, DOI:10.32604/phyton.2023.046943

    Abstract Habanero pepper (Capsicum chinense Jacq.) is a crop of economic relevance in the Peninsula of Yucatan. Its fruits have a high level of capsaicinoids compared to peppers grown in other regions of the world, which gives them industrial importance. Soil is an important factor that affects pepper development, nutritional quality, and capsaicinoid content. However, the effect of soil type on fruit development and capsaicinoid metabolism has been little understood. This work aimed to compare the effect of soils with contrasting characteristics, black soil (BS) and red soil (RS), on the expression of genes related to the development of fruits, and… More >

  • Open Access

    ARTICLE

    Candidate oncogene placenta specific 8 affects cell growth and cell migration in non-small cell lung cancers

    JINNI MA#, MEILIN ZHOU#, XIN XU, XINYAO GAO, HAIXIA WANG, JINHUA SHEN, LU XUE*

    BIOCELL, Vol.48, No.2, pp. 239-252, 2024, DOI:10.32604/biocell.2023.045076

    Abstract Background: Placenta specific 8 (PLAC8) is a candidate oncogene involved in the development and progression of solid tumors. However, the status of PLAC8 in lung cancer (LC), especially non-small cell lung cancer (NSCLC) is still not lucid. Methods: Tissue microarray analysis (TMA) was performed to detect the expression patterns of PLAC8 in LC tissues and cell lines. Then a series of cellular experiments were performed fto assess cell proliferation, cell cycle profiles, and cell motility to explore the role of PLAC8 in NSCLC-derived cell lines: H1299 and A549. Results: TMA results showed that PLAC8 played complex and even contradictory roles… More >

  • Open Access

    ARTICLE

    MicroRNA (let-7b-5p)-targeted DARS2 regulates lung adenocarcinoma growth by PI3K/AKT signaling pathway

    YUANYUAN XU, XIAOKE CHEN*

    Oncology Research, Vol.32, No.3, pp. 517-528, 2024, DOI:10.32604/or.2023.030293

    Abstract Background: The aberrant intracellular expression of a mitochondrial aspartyl-tRNA synthetase 2 (DARS2) has been reported in human cancers. Nevertheless, its critical role and detailed mechanism in lung adenocarcinoma (LUAD) remain unexplored. Methods: Initially, The Cancer Genome Atlas (TCGA)-based Gene Expression Profiling Interactive Analysis (GEPIA) database () was used to analyze the prognostic relevance of DARS2 expression in LUAD. Further, cell counting kit (CCK)-8, immunostaining, and transwell invasion assays in LUAD cell lines in vitro, as well as DARS2 silence on LUAD by tumorigenicity experiments in vivo in nude mice, were performed. Besides, we analyzed the expression levels of p-PI3K (phosphorylated-Phosphotylinosital3… More >

  • Open Access

    ARTICLE

    Smad8 is involvement in follicular development via the regulation of granulosa cell growth and steroidogenesis in mice

    DAOLUN YU1, DEYONG SHE2, KAI GE1, LEI YANG1, RUINA ZHAN1, SHAN LU3,*, YAFEI CAI4,*

    BIOCELL, Vol.48, No.1, pp. 139-147, 2024, DOI:10.32604/biocell.2023.045884

    Abstract Background: SMAD family proteins (SMADs) are crucial transcription factors downstream of transforming growth factor beta (TGF-ß)/SMAD signaling pathways that have been reported to play a pivotal role in mammalian reproduction. However, the role of SMAD family member 8 (SMAD8, also known as SMAD9), a member of the SMAD family, in mammalian reproduction remains unclear. Methods: We employed RNA interference techniques to knock down Smad8 expression in mouse granulosa cells (GCs) to investigate the effects of Smad8 on GC growth and steroidogenesis. Results: Our findings revealed a significant decrease in the proliferative capacity and a substantial increase in the apoptosis rate… More >

  • Open Access

    ARTICLE

    Silicon Mitigates Aluminum Toxicity of Tartary Buckwheat by Regulating Antioxidant Systems

    Anyin Qi1,#, Xiaonan Yan1,#, Yuqing Liu1,#, Qingchen Zeng1, Hang Yuan1, Huange Huang1, Chenggang Liang2, Dabing Xiang1, Liang Zou1, Lianxin Peng1, Gang Zhao1, Jingwei Huang1,*, Yan Wan1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 1-13, 2024, DOI:10.32604/phyton.2023.045802

    Abstract

    Aluminum (Al) toxicity is a considerable factor limiting crop yield and biomass in acidic soil. Tartary buckwheat growing in acidic soil may suffer from Al poisoning. Here, we investigated the influence of Al stress on the growth of tartary buckwheat seedling roots, and the alleviation of Al stress by silicon (Si), as has been demonstrated in many crops. Under Al stress, root growth (total root length, primary root length, root tips, root surface area, and root volume) was significantly inhibited, and Al and malondialdehyde (MDA) accumulated in the root tips. At the same time, catalase (CAT) and ascorbate peroxidase activities,… More >

  • Open Access

    PROCEEDINGS

    Thermodynamic Investigation with Synergetic Method on Inner Crack Growth Behavior at very High Cycle Fatigue Regime

    Yujia Liu1,2, Bo Xu1, Sen Tang3, Lang Li1, Chao He1, Qingyuan Wang1,2,3, Chong Wang1,2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.010057

    Abstract This paper presents a thermodynamic characterization method for estimating the internal crack growth rate, which has been a puzzle in very high cycle fatigue research. A theoretical approach of surface temperature is established with crack size, initiation site, and time for thin sheet material. Infrared thermography is used to study the inner crack behavior and the heat dissipation phenomenon under 20 kHz vibration loading on high-strength stainless steel. A numerical simulation reveals the consequent temperature elevation on the surfaces by the heat generation at the crack tip and the heat conduction. Ultimately, the internal crack growth rate and final fatigue… More >

  • Open Access

    PROCEEDINGS

    A Modified Rate-Dependent Peridynamic Model with Rotation Effect for Dynamic Mechanical Behavior of Ceramic Materials

    Yaxun Liu1,2, Lisheng Liu1,2,*, Hai Mei1,2, Qiwen Liu1,2, Xin Lai1,2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09007

    Abstract As a mathematical expression of the dynamic mechanical behavior, the constitutive model plays an indispensable role in numerical simulations of ceramic materials. The current bond-based peridynamic constitutive models can accurately describe the dynamic mechanical behavior of partial ceramic materials under impact loading, however, the predicted value of the Poisson’s ratio is 0.25, which is not true for most of the known ceramic materials. Herein, based on the existing bond-based peridynamic constitutive model, the current study utilizes the description of tangential bond force and considers the influence of bond force on rotation to accurately predict the Poisson's ratio of different types… More >

  • Open Access

    ARTICLE

    Associations between Mental Health Outcomes and Adverse Childhood Experiences and Character Strengths among University Students in Southern China

    Yulan Yu1,2, Rassamee Chotipanvithayakul3, Hujiao Kuang4, Wit Wichaidit3,*, Chonghua Wan1,2,*

    International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1343-1351, 2023, DOI:10.32604/ijmhp.2023.043446

    Abstract Adverse childhood experiences (ACEs) can negatively affect mental health, whereas character strengths seem to be positively correlated with mental health. Detailed information on the history of ACEs among university students in China and the extent which mental health is associated with ACEs and character strengths can contribute to the needed empirical evidence for relevant stakeholders. Objectives of this study are 1) to estimate the prevalence of ACEs among undergraduate students in Southern China; and 2) to assess the extent which mental health outcomes (positive growth, well-being, and depression) are associated with ACEs and character strengths among undergraduate students in Southern… More >

  • Open Access

    ARTICLE

    GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling

    TINGTING LI1, WEI ZHONG1, LIU YANG1, ZHIYU ZHAO1, LI WANG1, CONG LIU1, WANYUN LI1, HAIYAN LV2, SHENGYU WANG1, JIANGHUA YAN1, TING WU1,*, GANG SONG1,*, FANGHONG LUO1,*

    Oncology Research, Vol.32, No.2, pp. 361-371, 2024, DOI:10.32604/or.2023.043807

    Abstract The high mortality rate associated with gastric cancer (GC) has resulted in an urgent need to identify novel therapeutic targets for GC. This study aimed to investigate whether GAIP interacting protein, C terminus 1 (GIPC1) represents a therapeutic target and its regulating mechanism in GC. GIPC1 expression was elevated in GC tissues, liver metastasis tissues, and lymph node metastases. GIPC1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor (PDGFR)/PI3K/AKT signaling pathway, and inhibited the proliferation and migration of GC cells. Conversely, GIPC1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway, and promoted GC cell proliferation and migration. Furthermore,… More > Graphic Abstract

    GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling

  • Open Access

    ARTICLE

    Vaccinia-related kinase 2 variants differentially affect breast cancer growth by regulating kinase activity

    SEUNG-HEE GWAK1, JUHYUN LEE1, EUNJI OH1, DOHYUN LEE1,2, WONSHIK HAN3, JONGMIN KIM1,*, KYONG-TAI KIM4,*

    Oncology Research, Vol.32, No.2, pp. 421-432, 2024, DOI:10.32604/or.2023.031031

    Abstract Genetic information is transcribed from genomic DNA to mRNA, which is then translated into three-dimensional proteins. mRNAs can undergo various post-transcriptional modifications, including RNA editing that alters mRNA sequences, ultimately affecting protein function. In this study, RNA editing was identified at the 499th base (c.499) of human vaccinia-related kinase 2 (VRK2). This RNA editing changes the amino acid in the catalytic domain of VRK2 from isoleucine (with adenine base) to valine (with guanine base). Isoleucine-containing VRK2 has higher kinase activity than the valine-containing VRK2, which leads to an increase in tumor cell proliferation. Earlier we reported that VRK2 directly interacts… More > Graphic Abstract

    Vaccinia-related kinase 2 variants differentially affect breast cancer growth by regulating kinase activity

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