Di Yin*†1, Yang Li*1, Baofeng Guo‡, Zhewen Liu*, Yang Xu§, Xiaoqin Wang*, Yanwei Du*, Libo Xu*, Yan Meng*, Xuejian Zhao*, Ling Zhang*
Oncology Research, Vol.23, No.5, pp. 229-236, 2015, DOI:10.3727/096504016X14550280421449
Abstract RNA interference (RNAi) has been used for cancer gene therapy in recent years. However, the application of
RNAi is hindered in the absence of safe and efficient gene delivery. In this article, a novel vehicle of graphene
oxide functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) was successfully synthetized and then used to deliver plasmid-based Stat3 siRNA. The carrier can readily bind plasmid with high
transfection efficiency. Moreover, molecular biology studies reveal that Stat3-related gene and protein expressions were significantly inhibited, suggesting that the formation of GO-PEI-PEG complexes could be utilized
as a promising gene delivery More >
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