Yu Sun1, Kai Xu1, Miao He, Guilian Fan, Hongming Lu
Oncology Research, Vol.26, No.4, pp. 565-572, 2018, DOI:10.3727/096504017X15044461944385
Abstract Glypican 5 (GPC5) belongs to the family of heparan sulfate proteoglycans (HSPGs). It was initially known as a
regulator of growth factors and morphogens. Recently, there have been reports on its correlation with the tumorigenic process in the development of some cancers. However, little is known about its precise role in prostate
cancer (PCa). In the present study, we explored the expression pattern and biological functions of GPC5 in PCa
cells. Our results showed that GPC5 was lowly expressed in PCa cell lines. Upregulation of GPC5 significantly
inhibited PCa cell proliferation and invasion in vitro More >
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