BINGJIE LIN1, XIAOBO YING2, CHUANLING ZHANG3,*, GUOJUN ZHANG1,*
BIOCELL, Vol.48, No.11, pp. 1613-1623, 2024, DOI:10.32604/biocell.2024.053652
- 07 November 2024
Abstract Objectives: This study explores the protective effects of glycyrrhizic acid (GA) on sepsis-induced cellular damage and inflammation in acute lung injury (ALI), specifically through the modulation of the sirtuin 1 (SIRT1) and high mobility group box 1 (HMGB1) pathway. Methods: The study employed two experimental models: lipopolysaccharide (LPS)-induced BEAS-2B human lung epithelial cells and cecal ligation and puncture (CLP) rats, to simulate sepsis conditions. The cell model involved treatments with LPS, GA, control siRNA (si-NC), and SIRT1-specific siRNA (si-SIRT1). Evaluations included cell viability, apoptosis, and cytokine production. In the rat model, treatments included GA and… More >
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