LEI ZHONG1, LEI GUO1, ZHISHUAI YE2, SHANFENG ZHANG3, RONGCHONG HUANG2,*
BIOCELL, Vol.44, No.2, pp. 225-236, 2020, DOI:10.32604/biocell.2020.08714
- 27 May 2020
Abstract Studies have found that a large number of inflammatory cells, P-selectin, and mature dendritic cells (DCs) are
expressed in the damaged and shoulder parts of atherosclerotic plaque, which demonstrates that P-selectin and mature
DCs participate in the immune inflammatory response leading to the development of atherosclerosis. However, it is
unclear how the above factors interact in this setting. In this study, we investigated the role of P-selectin and its
receptor, P-selectin glycoprotein ligand (PSGL)-1 in atherosclerosis, with the finding that DC surface marker
expression was consistently high in the P-selectin group while consistently low in More >
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