Xiaoling Wu*1, Zhiqin Yang†1, Huimin Dang‡, Huixia Peng*, Zhijun Dai§
Oncology Research, Vol.26, No.4, pp. 645-653, 2018, DOI:10.3727/096504017X15031557924141
Abstract Baicalein, a flavonoid derived from the root of Scutellaria baicalensis, has been reported to possess multiple
pharmacological activities, such as anticancer and anti-inflammatory properties. This study investigated the
effect of baicalein in cervical cancer cells. Cell growth curve and MTT assay were performed and revealed
that baicalein inhibited the proliferation of SiHa and HeLa cells in a dose-dependent manner. We further found
that baicalein arrested the cell cycle of SiHa and HeLa cells at the G0/G1 phase by suppressing the expression
of cyclin D1 through the downregulation of phosphorylated protein kinase B (p-AKT) and phosphorylated
glycogen synthase More >
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