Amjed Al Fahoum^*, Ala’a Zyout, Hiam Alquran, Isam Abu-Qasmieh

CMC-Computers, Materials & Continua, Vol.76, No.1, pp. 1173-1193, 2023, DOI:10.32604/cmc.2023.038304 - 08 June 2023

Abstract Complex proteins are needed for many biological activities. Folding amino acid chains reveals their properties and functions. They support healthy tissue structure, physiology, and homeostasis. Precision medicine and treatments require quantitative protein identification and function. Despite technical advances and protein sequence data exploration, bioinformatics’ “basic structure” problem—the automatic deduction of a protein’s properties from its amino acid sequence—remains unsolved. Protein function inference from amino acid sequences is the main biological data challenge. This study analyzes whether raw sequencing can characterize biological facts. A massive corpus of protein sequences and the Globin-like superfamily’s related protein families… More >

Isam Abu-Qasmieh, Amjed Al Fahoum^*, Hiam Alquran, Ala’a Zyout

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 3971-3991, 2023, DOI:10.32604/cmc.2023.037431 - 31 March 2023

Abstract Proteins are essential for many biological functions. For example, folding amino acid chains reveals their functionalities by maintaining tissue structure, physiology, and homeostasis. Note that quantifiable protein characteristics are vital for improving therapies and precision medicine. The automatic inference of a protein’s properties from its amino acid sequence is called “basic structure”. Nevertheless, it remains a critical unsolved challenge in bioinformatics, although with recent technological advances and the investigation of protein sequence data. Inferring protein function from amino acid sequences is crucial in biology. This study considers using raw sequencing to explain biological facts using… More >