YINGHUI GAO, DENGTAI WEN*, SHIJIE WANG, JINGFENG WANG
BIOCELL, Vol.47, No.1, pp. 41-49, 2023, DOI:10.32604/biocell.2022.022689
- 26 September 2022
Abstract Presenilin (Psn) protein is associated with organismal aging. Mutations in the Psn gene may lead to Alzheimer’s
disease (AD), dilated cardiomyopathy (DCM), and many age-dependent degenerative diseases. These diseases seriously
affect the quality of life and longevity of the population and place a huge burden on health care and economic systems
around the world. Humans have two types of Psn, presenilin-1 (PSEN1) and presenilin-2 (PSEN2). Mutations in the
genes encoding PSEN1, PSEN2, and amyloid precursor protein (APP) have been identified as the major genetic
causes of AD. Psn is a complex gene strongly influenced by genetic and… More >
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