Hala Abdulaziz M ALWARTHAN1, Mohammad Saud AL ANAZI1, Narasimha R. PARINE1, Ramesa Shafi BHAT1,*, Ghadah ALAMRO1, Ftoon ALJARBOU1, Sooad K AL-DAIHAN1
BIOCELL, Vol.43, No.2, pp. 51-58, 2019, DOI:10.32604/biocell.2019.07019
Abstract Tankyrase1 plays an essential role in cancer progression by regulating telomere length. The study aimed
to determine expression of TNKS1 and its regulation in colorectal cancer (CRC) in 20 samples from Saudi patients.
mRNA expression of TNKS1 in CRC and paired normal tissues was measured by qRT-PCR. Epigenetic modification
of TNKS1 promoter was determined by methylation-specific PCR while somatic mutation was analyzed by Sanger
sequencing in exon 10 of the gene. All cancerous and normal tissues expressed TNKS1, but level of expression in CRC
tissues was significantly associated with tumor stage though no other parameters; age, gender,… More >
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