Wendong Jia^#, Ting Zhang^#, Ziying Zhang, Lingzhi Wu, Xihao Fu, Zhenxin Wang^*, Ni Yin^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068651 - 30 December 2025

Abstract Objectives: Chromobox 4 (CBX4), a polycomb protein family member linked to tumor pathogenesis via dysregulation, has an incompletely defined role in gastric cancer (GC). The study aimed to investigate the role and mechanism of CBX4 in GC progression and evaluate its potential as a therapeutic target. Methods: CBX4 expression was assessed in GC tissues vs. adjacent non-cancerous tissues and in GC cell lines vs. normal gastric mucosal epithelial cells. Clinicopathological correlations were analyzed. Functional impacts of CBX4 were determined using knockdown and overexpression models in vitro (cell proliferation, migration, invasion) and in vivo (xenograft tumorigenesis in nude… More >

Woo-Gyun Choi, Byung Joo Kim^*

BIOCELL, Vol.49, No.12, pp. 2365-2375, 2025, DOI:10.32604/biocell.2025.072715 - 24 December 2025

Abstract Objectives: Petasites japonicus (PJ) is a traditional medicinal herb widely used in East Asia for treating diverse ailments. However, its anticancer properties and underlying mechanisms have not been elucidated. This study investigated the anticancer potential and molecular mechanisms of the methanol extract of Petasites japonicus (PJE) in human adenocarcinoma gastric stomach (AGS) cells. Methods: AGS cells were treated with various concentrations of PJE, and cell viability was measured using MTT and CCK-8 assays. Apoptotic cell death was evaluated by the cell cycle, caspase-3 and -9 activity assays, and western blotting. To elucidate the underlying signaling mechanisms, we… More >

Ioannis A. Voutsadakis^1,2,3,*

Oncology Research, Vol.33, No.12, pp. 4073-4092, 2025, DOI:10.32604/or.2025.069230 - 27 November 2025

Abstract Background: E26 transformation-specific (ETS) family transcription factors have confirmed roles in several types of cancers. This study aimed to clarify the role of ETS family transcription factor alterations in gastric cancers. Methods: This study examines molecular alterations of ETS transcription factors in gastric adenocarcinomas based on an analysis of publicly available cohorts from the Protein Atlas and the Cancer Genome Atlas. The expression and relationships of members of the ETS transcription factor family with other important factors in the process of gastric carcinogenesis were evaluated using the same resources. Results: mRNA expression levels of ETS family… More >

Yizhen Zhang^1,2,#, Juan Li^1,3,#, Huanqing Liu^1,4,#, Hong Xia¹, Jian Su^1,5, Fang Liu¹, Bo Su^6,*, Qi Su^1,*

Oncology Research, Vol.33, No.12, pp. 3869-3886, 2025, DOI:10.32604/or.2025.068689 - 27 November 2025

Abstract Objectives: Gastric cancer (GC) is often associated with high invasiveness, epithelial-mesenchymal transition (EMT), and resistance to 5-fluorouracil (5-FU), highlighting the need for novel therapeutic targets. This study explored whether diallyl disulfide (DADS) upregulates retinoic acid-related orphan receptor alpha (ROR) to weaken the protein kinase C alpha (PKC)/RORα-mediated RORα/β-catenin pathway, thereby inhibiting GC cell invasion, epithelial-mesenchymal transition (EMT), and enhancing 5-FU sensitivity. Methods: Human GC cell lines MGC-803 and SGC7901 were treated with DADS, RORα agonist SR1078/antagonist T0901317, and PKCα agonist TPA/antagonist GO6976. Cell proliferation (MTT), migration (scratch assay), invasion (Transwell), protein expression (Western blot), protein… More >

Xinke Chai, Shifeng Wu, Qian Shen, Qiulin Huang^*

Oncology Research, Vol.33, No.12, pp. 3731-3752, 2025, DOI:10.32604/or.2025.067546 - 27 November 2025

Abstract Gastric cancer (GC) is a prevalent malignant tumor globally, with high incidence and mortality rates. Advances in understanding molecular mechanisms underlying GC have highlighted the role of microRNAs (miRNAs) in its initiation, progression, and treatment. The Let-7 family, an important class of miRNAs, is closely associated with the biological behaviors of GC. Aberrant expression of various Let-7 family members in GC patients contributes to disease progression, as they target multiple molecular pathways and participate in diverse regulatory mechanisms throughout GC pathogenesis. This article systematically summarizes the expression patterns of Let-7 family members in GC, explores More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.11, pp. 3605-3605, 2025, DOI:10.32604/or.2025.074402 - 22 October 2025

Abstract This article has no abstract. More >

Ying Fang^1,2,3,#, Anqi Wu^2,4,#, Yu-Sheng Cong^5,*, Guoqing Li^1,2,*

Oncology Research, Vol.33, No.11, pp. 3231-3245, 2025, DOI:10.32604/or.2025.066402 - 22 October 2025

Abstract Gastric Cancer (GC) is a highly prevalent and poorly prognostic gastrointestinal malignancy with low overall treatment efficacy worldwide. Early diagnostic markers and potential therapeutic targets for GC treatment are urgently needed. UFMylation, a novel ubiquitin-like modification is indispensable for numerous fundamental cellular processes. Deficiency in this modification is reported to be associated with several human diseases including cancer. Accumulating evidence suggests that the expression of the key UFMylation components is closely associated with GC cell proliferation, invasion, metastasis, and chemotherapy resistance. Recent clinical studies have further highlighted the prognostic value and therapeutic potential of UFMylation More >

Yun Zhou^1,2, Shixiong Liu^1,2, Ya Zheng^1,3,4, Yuping Wang^1,3,4,*, Yongning Zhou^1,3,4,*

BIOCELL, Vol.49, No.10, pp. 1967-1983, 2025, DOI:10.32604/biocell.2025.069869 - 22 October 2025

Abstract Background: Gastric cancer (GC) is a prevalent cause of death. 3,9-Di-O-methylnissolin (DOM) is a flavonoid isolated from Astragalus membranaceus. It has anticancer and anti-inflammatory effects, but its effect and mechanism of action on GC are not very clear. Methods: The appropriate concentration was selected after observing the effects of varying concentrations of DOM on the viability of GC cells, which was examined through the cell counting kit-8 (CCK-8) assay. The receptor-interacting protein kinase 2 (RIPK2) overexpression plasmid was transfected into GC cells, which were then treated with DOM. Cell cycle and proliferation, RIPK2 levels, and inflammatory… More > Graphic Abstract

Songhua Bei^1,2,#, Qianqian Guo^1,#, Xinglei Wu^1,#, Fan Li^2,#, Yaya Xie³, Xiaohong Zhang^2,*, Li Feng^2,*, Xingxing Zhang^1,3,*

Oncology Research, Vol.33, No.10, pp. 3101-3125, 2025, DOI:10.32604/or.2025.067247 - 26 September 2025

Abstract Background: Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation, which has been linked to tumor progression and therapeutic resistance. However, the contribution of lactate metabolism and its receptor, hydroxycarboxylic acid receptor 1 (HCAR1), in ferroptosis regulation in gastric cancer (GC) remains poorly understood. Focusing specifically on its effects on cell proliferation, ferroptosis regulation, and the disruption of lactate-mediated metabolic pathways, the study aimed to clarify the role of HCAR1 in GC progression. Methods: Bioinformatics analysis identified prognostic genes associated with ferroptosis in GC. Receiver operating characteristic (ROC) curves were generated… More >

Fan Yang, Zhongbo Zhu, Lijuan Shi, Xiping Liu^*

BIOCELL, Vol.49, No.8, pp. 1413-1433, 2025, DOI:10.32604/biocell.2025.064982 - 29 August 2025

Abstract Gastric cancer remains a leading cause of cancer-related mortality worldwide, with its complex tumor microenvironment (TME) playing a crucial role in tumor initiation, progression, and therapeutic response. As key components of the TME, mesenchymal stem cells (MSCs) influence tumor cell proliferation, invasion, and treatment resistance through cytokine secretion, exosomal communication, and metabolic regulation. MSCs enhance cancer stemness and therapy resistance by modulating glycolysis and fatty acid oxidation (FAO), while also promoting tumor progression through immune modulation and interactions with surrounding microenvironmental elements. Despite their potential for therapeutic applications, the clinical use of MSCs in gastric… More >