Yuguo YI, Jiamin ZHENG, Yang ZHOU, Zhiqin LIU, Dan WENG*
BIOCELL, Vol.44, No.1, pp. 7-11, 2020, DOI:10.32604/biocell.2020.08686
- 01 March 2020
Abstract Nonalcoholic fatty liver disease (NAFLD) represents a huge threat to public health of the whole world.
Around 25% of NAFLD patients will progress to nonalcoholic steatohepatitis (NASH), which has been predicted to be
the main reason for liver transplantation in the United States in 2020. Extensive effort has been devoted to investigating
the underlying molecular mechanisms of NASH pathogenesis and developing new promising treatments. Recent
studies have demonstrated that pyroptosis, an inflammatory programmed cell death mediated by inflammasome and
gasdermin-D (GSDMD), is involved in the development and progression of NASH. This review aims to summarize More >
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