QINGYANG ZHANG, SHUXIAN HUANG, DAN WENG^*

BIOCELL, Vol.48, No.10, pp. 1443-1453, 2024, DOI:10.32604/biocell.2024.053794 - 02 October 2024

Abstract Huntington’s disease (HD) is a debilitating neurodegenerative disorder caused by an abnormal expansion of CAG repeats (Cytosine, Adenine, Guanine) in the huntingtin gene (HTT). This mutation leads to the production of a mutant huntingtin protein, resulting in neuronal dysfunction and cell death. Current treatments primarily focus on symptomatic relief and do not address the underlying genetic cause. This review explores spliceosome-mediated RNA trans-splicing (SMaRT) therapy as an innovative and potential approach for HD treatment. SMaRT leverages the cell’s natural splicing machinery to correct mutant mRNA, thereby reducing toxic protein levels while restoring functional protein production. We More >

S. Devi Mahalakshmi^*

Computer Systems Science and Engineering, Vol.44, No.2, pp. 1387-1395, 2023, DOI:10.32604/csse.2023.027610 - 15 June 2022

Abstract The kidney is an important organ of humans to purify the blood. The healthy function of the kidney is always essential to balance the salt, potassium and pH levels in the blood. Recently, the failure of kidneys happens easily to human beings due to their lifestyle, eating habits and diabetes diseases. Early prediction of kidney stones is compulsory for timely treatment. Image processing-based diagnosis approaches provide a greater success rate than other detection approaches. In this work, proposed a kidney stone classification method based on optimized Transfer Learning(TL). The Deep Convolutional Neural Network (DCNN) models More >

Kazuhiko Kakuda^1,*, Asuka Iizumi¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.24, No.1, pp. 1-5, 2022, DOI:10.32604/icces.2022.08695

Abstract In this paper, we present the dynamic behaviors of crown formation, central jet, and secondary droplets generated with droplet impact onto a liquid surface by using experimental and computational approaches. In our experiment, the dynamic behaviors after a droplet impact are recorded using a high-speed camera with appropriate resolution and exposure time. On the other hand, we simulate numerically the similar behaviors using the VOF (volume of fluid) solver in the OpenFOAM. As a fluid field, we consider the multiphase flows with free surfaces based on incompressible Navier-Stokes equations in the software codes. Some qualitative More >

Mohammad Jawaid¹, Lau Kia Kian¹, Hassan Fouad², Ramzi Khiari^3,4,5,*, Othman Y. Alothman⁶, Mohamed Hashem⁷

Journal of Renewable Materials, Vol.10, No.6, pp. 1459-1470, 2022, DOI:10.32604/jrm.2022.018415 - 20 January 2022

Abstract Cellulose nanocrystal (CNC) is a biomaterial derived from plant lignocellulosic components, widely applied in various industrial fields. Concurrently, with the growth of awareness in developing green nanomaterial, the explored Washingtonia fibre could be alternative biomass for obtaining CNC products. In the present work, different acid concentrations of 5%, 15%, and 25% hydrochloric solutions were employed to produce CNCs from Washingtonia fibre. With the chemical treatments, the yield of the CNC product was successfully retained at 21.6%−25.1%. Individually separated and needle-shaped CNC particles could be observed under the microscopic viewing with the increased acid concentrations. From… More > Graphic Abstract