Xiaoling Wu^*1, Zhiqin Yang^†1, Huimin Dang^‡, Huixia Peng^*, Zhijun Dai^§

Oncology Research, Vol.26, No.4, pp. 645-653, 2018, DOI:10.3727/096504017X15031557924141

Abstract Baicalein, a flavonoid derived from the root of Scutellaria baicalensis, has been reported to possess multiple pharmacological activities, such as anticancer and anti-inflammatory properties. This study investigated the effect of baicalein in cervical cancer cells. Cell growth curve and MTT assay were performed and revealed that baicalein inhibited the proliferation of SiHa and HeLa cells in a dose-dependent manner. We further found that baicalein arrested the cell cycle of SiHa and HeLa cells at the G₀/G₁ phase by suppressing the expression of cyclin D1 through the downregulation of phosphorylated protein kinase B (p-AKT) and phosphorylated glycogen synthase More >

Rong Wang, Yunfeng Wu, Weihua Huang, Weijun Chen

Oncology Research, Vol.26, No.1, pp. 145-155, 2018, DOI:10.3727/096504017X14902261600566

Abstract In this report, we aimed to explore the role and regulatory mechanism of microRNA-940 (miR-940) in bladder cancer development. The expressions of miR-940 in bladder cancer tissues and cells were measured. miR-940 mimics, miR-940 inhibitor small interference RNA against INPP4A (si-INPP4A), and GSK3b (si-GSK3b) and their corresponding controls were then transfected into cells. We investigated the effects of miR-940, INPP4A, or GSK3b on cell proliferation, migration, invasion, and apoptosis. Additionally, target prediction and luciferase reporter assays were performed to investigate the targets of miR-940. The regulatory relationship between miR-940 and the Wnt/β-catenin pathway was also… More >

Wei Wei^*1, Xiao-Dong Ma^†1, Guan-Min Jiang^‡, Bin Shi^§, Wen Zhong^¶, Chun-Lei Sun^§, Liang Zhao^*, Yan-Jiao Hou^*, Hao Wang^*

Oncology Research, Vol.28, No.4, pp. 423-438, 2020, DOI:10.3727/096504020X15877284857868

Abstract Although oxaliplatin serves as one of the first-line drugs prescribed for treating colorectal cancer (CRC), the therapeutic effect is disappointing due to drug resistance. So far, the molecular mechanisms mediating oxaliplatin resistance remain unclear. In this study, we found the chemoresistance in oxaliplatin-resistant HCT116 cells (HCT116/OXA) was mediated by the upregulation of ERCC1 expression. In addition, the acquisition of resistance induced epithelial–mesenchymal transition (EMT) as well as the Slug overexpression. On the contrary, Slug silencing reversed the EMT phenotype, decreased ERCC1 expression, and ameliorated drug resistance. Further mechanistical studies revealed the enhanced Slug expression resulted More >