VIRGINIA LOTTI1, GAETANO DE SIENA2, STEFANO BACCI3,*
BIOCELL, Vol.48, No.12, pp. 1751-1759, 2024, DOI:10.32604/biocell.2024.057904
- 30 December 2024
Abstract Background: Impaired wound healing is one of the most well-known complications of type 2 diabetes mellitus. Experimental evidence suggested that treatment with Exendin-4, a glucagon-like peptide-1 agonist displaying a wide range of antidiabetic effects, can promote tissue regeneration. Objectives: Thus, this study aimed to examine the efficacy of topical treatment with Exendin-4 in accelerating wound healing in normoglycemic and hyperglycemic mice. Methods: For this purpose, two wounds inflicted on the back skin of 12 normo- and 12 hyperglycemic mice were injected intradermally with either saline solution or Exendin-4. Wounds were collected at the time of abrasion… More >
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