Ao Zhan*, Bo Lei*, Honggang Wu*, YueTao Wen†, Liandong Zheng*, Shan Wang*, Xiaoqiang Wan*, Zhenghong Wei*
Oncology Research, Vol.25, No.5, pp. 831-842, 2017, DOI:10.3727/096504016X14816726393937
Abstract Gliomas are the most common and aggressive type of primary adult brain tumors. Although GGNBP2 has previously been considered to be a tumor suppressor gene, little is known about the association between GGNBP2
and glioma. In this study, we clearly demonstrated that GGNBP2 was downexpressed in glioma tissues, and its
downexpression is related to the pathological grade and overall survival of patients with gliomas. Overexpression
of GGNBP2 suppressed the proliferation, migration, and invasion of glioma cells. Mechanistically, we demonstrated that the PI3K/Akt and Wnt/β-catenin signaling pathways were suppressed by GGNBP2 overexpression.
In contrast, knockdown of More >
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