XIAOBI HUANG^1,#, CHUNYUAN CHEN², YONGYANG CHEN^1,#, HONGLIAN ZHOU¹, YONGHUA CHEN¹, ZHONG HUANG¹, YULIU XIE¹, BAIYANG LIU¹, YUDONG GUO¹, ZHIXIONG YANG¹, GUANGHUA CHEN^3,*, WENMEI SU^1,4,*

Oncology Research, Vol.32, No.7, pp. 1185-1195, 2024, DOI:10.32604/or.2023.030771

Abstract Background: Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes. Their dysregulation has been closely associated with tumorigenesis. LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer. However, the mechanism underlying its function in cancer progression remains poorly understood. Methods: Here, the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines, clinical samples, and xenografts. Results: We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients, whereas knockdown of LINC00265 inhibited proliferation… More >

LITING WEN^#, XIAOXIA ZENG^#, PEIXIONG CHEN, DAPENG ZHAO, YANGYANG LI, XIANHAI ZENG^*

BIOCELL, Vol.48, No.6, pp. 991-999, 2024, DOI:10.32604/biocell.2024.050219

Abstract Background: Cochlear hair cell injury is a common pathological feature of hearing loss. The basic helix-loop-helix family, member e40 (Bhlhe40), a gene belonging to the basic helix-loop-helix (bHLH) family, exhibits strong transcriptional repression activity. Methods: Oxidative damage, in House Ear Institute-Organ of Corti 1 (HEI‑OC1) cells, was caused using hydrogen peroxide (HO). The Ad-Bhlhe40 particles were constructed to overexpress Bhlhe40 in HEI-OC1 cells. Various assays including cell counting kit-8 (CCK-8), terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay (TUNEL), flow cytometry, immunofluorescence, and corresponding commercial kits were employed to investigate the impacts of Bhlhe40 on cell viability, apoptosis,… More > Graphic Abstract

Abeer H. Falih^*, Basima Salman Khalaf, Basim Freegah

Frontiers in Heat and Mass Transfer, Vol.22, No.2, pp. 597-613, 2024, DOI:10.32604/fhmt.2024.049812

Abstract In this study, the primary objective was to enhance the hydrothermal performance of a dimpled tube by addressing areas with low heat transfer compared to other regions. To accomplish this, a comprehensive numerical investigation was conducted using ANSYS Fluent 2022 R1 software, focusing on different diameters of dimples along the pipe’s length and the distribution of dimples in both in-line and staggered arrangements. The simulations utilized the finite element method to address turbulent flow within the tube by solving partial differential equations, encompassing Re numbers spanning from 3000 to 8000. The study specifically examined single-phase… More > Graphic Abstract

Zheng Yang, Ke Gu^*, Yiming Zuo

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2813-2831, 2024, DOI:10.32604/cmc.2024.050025

Abstract Federated learning is widely used to solve the problem of data decentralization and can provide privacy protection for data owners. However, since multiple participants are required in federated learning, this allows attackers to compromise. Byzantine attacks pose great threats to federated learning. Byzantine attackers upload maliciously created local models to the server to affect the prediction performance and training speed of the global model. To defend against Byzantine attacks, we propose a Byzantine robust federated learning scheme based on backdoor triggers. In our scheme, backdoor triggers are embedded into benign data samples, and then malicious More >

Feng Sheng^1,*, Chen Kong², Chao Li³

International Journal of Mental Health Promotion, Vol.26, No.3, pp. 221-228, 2024, DOI:10.32604/ijmhp.2024.030209

Abstract Objective: This study was conducted to explore the relationships among sedentary behavior (SB), electronic product addiction (EPA), and depression (D) in adolescents during the COVID-19 epidemic. Methods: A total of 604 adolescents (including 309 girls and 295 boys aged 12–18) were selected from Qufu City, Shandong Province, China for three rounds of investigation. The model was constructed using AMOS 23.0 software, and cross-lagged analysis was conducted. Results: SB at T1 can significantly positively predict SB and EPA at T2 (p < 0.05). EPA at T1 can significantly positively predict SB and D at T2 (p < 0.05). More >

JUNYING XU^1,#, PING LI^1,#, GE WANG², DAQIANG YE^1,*, XIUFU TANG^3,*

BIOCELL, Vol.48, No.2, pp. 283-291, 2024, DOI:10.32604/biocell.2023.045429

Abstract Background: α7 nicotinic acetylcholine receptor (α7nAChR) has been demonstrated to be involved in numerous of inflammatory diseases. Cell pyroptosis is a kind of cell death accompanied by inflammation. Objectives: The objective of this work is to explore the function of α7nAChR on cell pyroptosis in cervical cancer cells. Methods: Immunoblotting, quantitative polymerase chain reaction, and enzyme-linked immunosorbent assay were employed to examine the function of α7nAChR on cell pyroptosis and metabolic changes. Results: Herein, we found that α7nAChR inhibition led to cell pyroptosis in HeLa and SiHa of cervical cancer cells, which was attributed to the… More >

Husam Rashid Hudear^*, Saad Najeeb Shehab

Frontiers in Heat and Mass Transfer, Vol.21, pp. 367-383, 2023, DOI:10.32604/fhmt.2023.042639

Abstract This paper presents a numerical emulation study of heat transmission through tube banks in three-dimensions. Staggered configuration is displayed by fluid dynamics using computer programs (CFD) software (ANSYS fluent). The computer model is used to predict the values of the Nusselt number when changing the values of heat flux and longitudinal pitch. The longitudinal pitch (SL/D) of 1.3, 1.8, and 2.4 mm. The transverse pitch (ST/D) of 1.5 mm, and also considered Reynolds numbers 10000, 13000, 17000, and 190000. The staggered configuration of the tube bundle is demonstrated to investigate the impact of this arrangement More >

Mainak Bhaumik¹, Anirban Sur^2,*, Kavita Dhanawade³

Frontiers in Heat and Mass Transfer, Vol.21, pp. 467-486, 2023, DOI:10.32604/fhmt.2023.044605

Abstract Pin fins are widely used in applications where effective heat transfer is crucial. Their compact design, high surface area, and efficient heat transfer characteristics make them a practical choice for many thermal management applications. But for a high heat transfer rate and lightweight application, aerofoil shape pin fins are a good option. This work focuses on an experimental model analysis of pin-fins with aerofoil shapes. The results were evaluated between perforation, no perforation, inline, and staggered fin configurations. Aluminum is used to make the pin fins array. The experiment is carried out inside a wind… More >

Xiaojie Cao¹, Qinyu Zhang², Xinqiao Liu^3,*

International Journal of Mental Health Promotion, Vol.25, No.9, pp. 1009-1018, 2023, DOI:10.32604/ijmhp.2023.029365

Abstract The relationship between physical activity time, openness and depression symptoms among adolescents is a cutting-edge research direction in the field, yet it remains unclear. This study is based on a sample of 7924 students from a nationally representative China Education Panel Survey database and examines the bidirectional relationships between physical activity time, openness and depression symptoms among Chinese adolescents. Descriptive analysis showed that during the 7th and 8th grades, the average physical activity time decreased to less than one hour per day, accompanied by a decreasing trend in openness and a slight worsening in depression… More >

M. Atikur Rahman^*, Amranur Rahman, Arman Hossain, Arifur Rahman Bhuiyan

Journal of New Media, Vol.5, No.1, pp. 33-43, 2023, DOI:10.32604/jnm.2023.038676

Abstract As a result of the introduction of new infectious illnesses, key infection prevention measures were implemented. Now, a new coronavirus (SARS-CoV-2) epidemic has expanded swiftly, causing the coronavirus illness 2019 (COVID-19). Many microorganisms spread illness via hospital surfaces due to environmental pollution. This virus has been associated to close contact between persons in tight situations such as houses, hospitals, assisted living, and residential institutions. Aside from health care settings, public buildings, faith-based community centers, marketplaces, transportation, and corporate environments are prone to COVID-19 transmission. Physical contact to the sanitizer device may cause for spread Covid More >