Xunguang Yan^1,2, Wenrui Wang¹, Fanglin Lu¹, Hongyong Fan³, Bo Wu¹, Jianfeng Yu^1,*

CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 1439-1458, 2025, DOI:10.32604/cmc.2024.057797 - 03 January 2025

Abstract To maintain the reliability of power systems, routine inspections using drones equipped with advanced object detection algorithms are essential for preempting power-related issues. The increasing resolution of drone-captured images has posed a challenge for traditional target detection methods, especially in identifying small objects in high-resolution images. This study presents an enhanced object detection algorithm based on the Faster Region-based Convolutional Neural Network (Faster R-CNN) framework, specifically tailored for detecting small-scale electrical components like insulators, shock hammers, and screws in transmission line. The algorithm features an improved backbone network for Faster R-CNN, which significantly boosts the More >

WEI ZHANG^1,3,#, WEICHENG WANG^1,#, RUI WANG¹, XIAO HAN¹, LIJUN ZHU¹, WENJIE GUO^2,*, YANHONG GU^1,*

Oncology Research, Vol.33, No.1, pp. 225-234, 2025, DOI:10.32604/or.2024.050047 - 20 December 2024

Abstract Background: As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC. Methods and Materials: We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against tumors.… More > Graphic Abstract

Zhao-Jun Zhang¹, Wen-Wei Wang^1,2,*, Jing-Shui Zhen¹, Bo-Cheng Li¹, De-Cheng Cai¹, Yang-Yang Du¹, Hui Huang²

Structural Durability & Health Monitoring, Vol.19, No.1, pp. 105-123, 2025, DOI:10.32604/sdhm.2024.052506 - 15 November 2024

Abstract This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer (GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment zone. An experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs, and a calculation method based on the conjugate beam method was proposed. The composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab specimens. Two methods, epoxy resin bonding, and stud connection, were used to connect the composite… More >

Muhd Azimin bin Ab Ghani¹, Zhongwei Guan^2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.011074

Abstract Thermoplastic polyurethane (TPU) offers a superior impact and perforation resistance. This paper presents a study on manufacturing a range of hybrid laminated structures made of TPU, glass fibre reinforced plastic (GFRP), styrene-butadiene rubber (SBR) and metal mesh materials, and further on investigating the structural response of the TPU based composite sandwich laminated structures. These laminated structures were tested under quasi-static perforation and low velocity impact loading to determine their structural responses and energy absorption characteristics. It has been shown that three-layer and five-layer laminates with lay-ups of GFRP-TPU-GFRP or TPU-GFRP-TPU and GFRP-TPU-GFRP-TPU-GFRP or TPU-GFRP-TPU-GFRP-TPU subjected… More >

CHAOQUN WANG¹, TING ZHANG², CHAOHE ZHANG^3,*

Oncology Research, Vol.32, No.12, pp. 1867-1879, 2024, DOI:10.32604/or.2024.044547 - 13 November 2024

Abstract Background: Drug resistance is the main factor contributing to cancer recurrence and poor prognosis. Exploration of drug resistance-related mechanisms and effective therapeutic targets are the aim of molecular targeted therapy. In our study, the role of long non-coding RNA (lncRNA) AFAP1-AS1 in gemcitabine resistance and related mechanisms were explored in cervical cancer cells. Methods: Gemcitabine-resistant cervical cancer cell lines HT-3-Gem and SW756-Gem were constructed using the gemcitabine concentration gradient method. The overall survival rates and recurrence-free survival rates were evaluated by Kaplan-Meier analysis. The interaction was verified through a Dual-luciferase reporter gene assay and a… More > Graphic Abstract

SHAIL RAKESH MODI, TERRICK ANDEY^*

Oncology Research, Vol.32, No.11, pp. 1709-1721, 2024, DOI:10.32604/or.2024.053972 - 16 October 2024

Abstract Objectives: EGFR tyrosine kinase inhibitor (EGFR-TKI) therapies such as erlotinib and gefitinib are approved for the treatment of non-small cell lung cancer (NSCLC). However, the high incidence of acquired resistance to these EGFR-TKIs may preclude their effectiveness. Piperlongumine (PPL), an extract from the long pepper fruit (Piper longum), has been shown to possess anticancer properties. The purpose of the study was to investigate piperlongumine as an anticancer agent and to study a combination treatment approach with EGFR-TKIs against lung cancer cells. Methods: Anticancer efficacy of PPL, erlotinib (ERL), gefitinib (GEF), and cisplatin (CIS) were investigated in… More >

JI SHI^1,2, YE ZHANG², YI CHEN², TANGJUN GUO^3,*, HAOZHE PIAO^2,*

BIOCELL, Vol.48, No.8, pp. 1241-1263, 2024, DOI:10.32604/biocell.2024.051049 - 02 August 2024

Abstract Background: Glioblastoma multiforme (GBM) is the most general malignancy of the primary central nervous system that is characterized by high aggressiveness and lethality. Transmembrane protein 159 (TMEM159) is an endoplasmic reticulum protein that can form oligomers with seipin. The TMEM159-seipin complex decides the site of lipid droplet (LD) formation, and the formation of LDs is a marker of GBM. However, the role of TMEM159 in the progression of GBM has not been investigated to date. Methods: In this study, we examined the genes that may be associated with patient prognosis in GBM by bioinformatics analyses,… More >

YUE ZHANG^1,#, WENYU YANG^1,#, XIAOWANG HAN^1,#, YUE QIAO¹, HAITAO WANG², TING CHEN¹, TIANYING LI¹, WEN-BIN OU^1,*

Oncology Research, Vol.32, No.6, pp. 1119-1128, 2024, DOI:10.32604/or.2024.045025 - 23 May 2024

Abstract It has been shown that the high expression of human epididymis protein 4 (HE4) in most lung cancers is related to the poor prognosis of patients, but the mechanism of pathological transformation of HE4 in lung cancer is still unclear. The current study is expected to clarify the function and mechanism of HE4 in the occurrence and metastasis of lung adenocarcinoma (LUAD). Immunoblotting evaluated HE4 expression in lung cancer cell lines and biopsies, and through analysis of The Cancer Genome Atlas (TCGA) dataset. Frequent HE4 overexpression was demonstrated in LUAD, but not in lung squamous… More >

ANDI ZHAO^1,2,#, YUE WANG^3,#, ZIJIN WANG^1,2, QING SHAO^1,2, QI GONG^1,2, HUI ZHU^1,2, SHIYA SHEN^1,2, HU LIU^1,2,*, XUEJUAN CHEN^1,2,*

Oncology Research, Vol.32, No.5, pp. 983-998, 2024, DOI:10.32604/or.2024.045972 - 23 April 2024

Abstract Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like… More > Graphic Abstract

TINGTING LI¹, WEI ZHONG¹, LIU YANG¹, ZHIYU ZHAO¹, LI WANG¹, CONG LIU¹, WANYUN LI¹, HAIYAN LV², SHENGYU WANG¹, JIANGHUA YAN¹, TING WU^1,*, GANG SONG^1,*, FANGHONG LUO^1,*

Oncology Research, Vol.32, No.2, pp. 361-371, 2024, DOI:10.32604/or.2023.043807 - 28 December 2023

Abstract The high mortality rate associated with gastric cancer (GC) has resulted in an urgent need to identify novel therapeutic targets for GC. This study aimed to investigate whether GAIP interacting protein, C terminus 1 (GIPC1) represents a therapeutic target and its regulating mechanism in GC. GIPC1 expression was elevated in GC tissues, liver metastasis tissues, and lymph node metastases. GIPC1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor (PDGFR)/PI3K/AKT signaling pathway, and inhibited the proliferation and migration of GC cells. Conversely, GIPC1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway, and promoted GC More > Graphic Abstract