I Wayan Sumardika*†, Chen Youyi*, Eisaku Kondo‡, Yusuke Inoue§, I Made Winarsa Ruma*†, Hitoshi Murata*, Rie Kinoshita*, Ken-Ichi Yamamoto*, Shuta Tomida¶, Kazuhiko Shien#, Hiroki Sato#, Akira Yamauchi**, Junichiro Futami††, Endy Widya Putranto‡‡, Toshihiko Hibino§§, Shinichi Toyooka¶#¶¶, Masahiro Nishibori##, Masakiyo Sakaguchi*
Oncology Research, Vol.26, No.3, pp. 431-444, 2018, DOI:10.3727/096504017X15031557924123
Abstract We previously identified novel S100A8/A9 receptors, extracellular matrix metalloproteinase inducer
(EMMPRIN), melanoma cell adhesion molecule (MCAM), activated leukocyte cell adhesion molecule
(ALCAM), and neuroplastin (NPTN) β, that are critically involved in S100A8/A9-mediated cancer metastasis
and inflammation when expressed at high levels. However, little is known about the presence of any cancerspecific mechanism(s) that modifies these receptors, further inducing upregulation at protein levels without any
transcriptional regulation. Expression levels of glycosyltransferase-encoding genes were examined by a PCRbased profiling array followed by confirmation with quantitative real-time PCR. Cell migration and invasion
were assessed using a Boyden chamber.… More >
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