Abdul Sattar Laghari¹, Mohammad Waqas Chandio¹, Laveet Kumar^2,*, Mamdouh El Haj Assad³

Energy Engineering, Vol.121, No.8, pp. 2023-2038, 2024, DOI:10.32604/ee.2024.051082

Abstract The selection of working fluid significantly impacts the geothermal ORC’s Efficiency. Using a mixture as a working fluid is a strategy to improve the output of geothermal ORC. In the current study, modelling and thermodynamic analysis of ORC, using geothermal as a heat source, is carried out at fixed operating conditions. The model is simulated in the Engineering Equation Solver (EES). An environment-friendly mixture of fluids, i.e., R245fa/R600a, with a suitable mole fraction, is used as the operating fluid. The mixture provided the most convenient results compared to the pure working fluid under fixed operating More >

Ponusa Songtipya^1,2,*, Thummanoon Prodpran^1,2, Ladawan Songtipya^1,2, Theerarat Sengsuk¹

Journal of Renewable Materials, Vol.12, No.5, pp. 951-967, 2024, DOI:10.32604/jrm.2024.049068

Abstract The synergistic effect of organoclay (OC) and zinc oxide (ZnO) nanoparticles on the crucial properties of poly(lactic acid) (PLA) nanocomposite films was systematically investigated herein. After their incorporation into PLA via the solvent casting technique, the water vapor barrier property of the PLA/OC/ZnO film improved by a maximum of 86% compared to the neat PLA film without the deterioration of Young’s modulus or the tensile strength. Moreover, the film’s self-antibacterial activity against foodborne pathogens, including gram-negative (Escherichia coli, E. coli) and gram-positive (Staphylococcus aureus, S. aureus) bacteria, was enhanced by a maximum of approximately 98–99% compared to the neat… More > Graphic Abstract

DAN GUO¹, XI XIA^2,*, JIAN YANG^1,*

BIOCELL, Vol.48, No.7, pp. 1023-1036, 2024, DOI:10.32604/biocell.2024.051095

Abstract Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine. In recent years, the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical requirements. This review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver failure. Here, we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver failure. Furthermore, we explored the challenges in transitioning More >

Qian Tao, Guiqi Han, Bujin Ma, Hongmei Jia, Can Zhao, Wenshang Li, Zhuyun Yan^*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1297-1310, 2024, DOI:10.32604/phyton.2024.051923

Abstract Fritillaria cirrhosa D. Don (Liliaceae) is an endangered perennial bulbous plant and its dry bulb is a valuable medicinal material with antitussive and expectorant effects. Nevertheless, lack of resources and expensive prices make it difficult to meet clinical needs. This study presents a regeneration system aimed at overcoming the challenge of inadequate supply in F. cirrhosa, focusing on: (1) callus induction, (2) bulblets and adventitious bud induction, and (3) artificial seed production. Callus development was achieved in 84.93% on Murashige and Skoog (MS) medium fortified with 1.0 mg·L picloram. The optimal medium for callus differentiation into regenerated… More >

Chuang Liu^1,2, Jing Xie², Hao Liu², Can Zhong², Gen Pan², Shuihan Zhang², Jian Jin^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1221-1236, 2024, DOI:10.32604/phyton.2024.050759

Abstract Medicinal plants have aroused considerable interest as an alternative to chemical drugs due to the beneficial effects of their active secondary metabolites. However, the extensive use of chemical fertilizers and pesticides in pursuit of yield has caused serious pollution to the environment, which is not conducive to sustainable development in the field of medicinal plants. Microbial fertilizers are a type of “green fertilizer” containing specific microorganisms that can improve the soil microbial structure, enhance plant resistance to biological and abiotic stresses, and increase the yield of medicinal plants. The root exudates of medicinal plants attract… More >

Yongguo Li^1,2, Caiyin Xu^1,2,*, Can Qin^1,2, Dingjian Zheng^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1251-1263, 2024, DOI:10.32604/fdmp.2023.044804

Abstract The so-called ORC (Organic Rankine Cycle) heat recovery technology has attracted much attention with regard to medium and low temperature waste heat recovery. In the present study, it is applied to a Tesla turbine. At the same time, the effects of the disc speed, diameter and inter-disc gap on the internal flow field and output power of the turbine are also investigated by means of CFD (Computational Fluid Dynamics) numerical simulation, by which the pressure, velocity, and output efficiency of the internal flow field are obtained under different internal and external conditions. The highest efficiency More >

Amerah Alabrah^*

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 3897-3912, 2024, DOI:10.32604/cmc.2024.048528

Abstract The emergence of digital networks and the wide adoption of information on internet platforms have given rise to threats against users’ private information. Many intruders actively seek such private data either for sale or other inappropriate purposes. Similarly, national and international organizations have country-level and company-level private information that could be accessed by different network attacks. Therefore, the need for a Network Intruder Detection System (NIDS) becomes essential for protecting these networks and organizations. In the evolution of NIDS, Artificial Intelligence (AI) assisted tools and methods have been widely adopted to provide effective solutions. However,… More >

Gamal A. Elfar^*†, Mohamed A. Ebrahim^‡, Nehal M. Elsherbiny^*, Laila A. Eissa^*

Oncology Research, Vol.25, No.4, pp. 641-650, 2017, DOI:10.3727/096504016X14768398678750

Abstract Osteoprotegerin (OPG) is a robust antiresorptive molecule that acts as a decoy receptor for the receptor activator of nuclear factor kB ligand (RANKL), the mediator of osteoclastogenesis. This study was designed to explore the possible role of serum OPG and RANKL in detecting bone metastasis in breast cancer and its interaction with clinicopathologic parameters. Serum levels of RANKL and OPG were estimated in 44 metastatic and 36 nonmetastatic breast cancer patients using ELISA kits. Serum OPG levels were significantly reduced in patients with bone metastasis and correlated negatively with the number of bone lesions and… More >

Feng Shuai^*, Bo Wang^†, Shuxiao Dong^‡

Oncology Research, Vol.26, No.8, pp. 1295-1305, 2018, DOI:10.3727/096504018X15172747209020

Abstract Among all of the miRNAs, miR-204 has gained considerable attention in the field of cancer research. This study aimed to reveal the detailed functions and the underlying mechanism of miR-204 in colorectal cancer (CRC) cells. The expressions of miR-204 in CRC tumor tissues and cell lines were monitored. Expressions of miR-204 and CXCL8 in Caco-2 and HT-29 cells were altered by transfection, and then cell viability, apoptosis, migration, invasion, EMT-related protein expression, and PI3K/AKT/mTOR pathway protein expression were assessed. We found that miR-204 was expressed at low levels in CRC tumor tissues and cell lines… More >

Sanae Haga^*, Akira Kanno^†, Takeaki Ozawa^‡, Naoki Morita^§, Mami Asano^*¶,¶ and Michitaka Ozaki^*¶

Oncology Research, Vol.26, No.3, pp. 503-513, 2018, DOI:10.3727/096504017X15005102445191

Abstract Liver injury is often observed in various pathological conditions including posthepatectomy state and cancer chemotherapy. It occurs mainly as a consequence of the combined necrotic and apoptotic types of cell death. In order to study liver/hepatocyte injury by the necrotic type of cell death, we studied signal-regulated necrosis (necroptosis) by developing a new optic probe for detecting receptor-interacting protein kinase 1 (RIP)/RIP3 binding, an essential process for necroptosis induction. In the mouse hepatocyte cell line, TIB-73 cells, TNF-a/cycloheximide (T/C) induced RIP1/3 binding only when caspase activity was suppressed by the caspase-specific inhibitor z-VAD-fmk (zVAD). T/C/zVAD-induced… More >