SHAOFENG XIONG^1,2, WENKAI LV³, GUOSHENG CAO⁴, LONGSHENG FU¹, WEN LIU³, MENGFAN LEI², YANNI LV^1,5,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.073401 - 23 January 2026

Abstract Objective: Leucine-rich alpha-2 glycoprotein 1 (Lrg1) could regulate diverse cells in cerebral ischemia-reperfusion. Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways and transcription factors. Method: The CSOmap model measured cell-to-brain-center distances using single-cell RNA sequencing (scRNA-seq) data in middle cerebral artery occlusion reperfusion (MCAO/R). Monocle2 mapped endothelial differentiation paths. Gene set enrichment analysis (GSEA) analyzed endothelial subcluster variations. Database searches revealed a zinc finger MIZ-type containing 1 protein-frizzled 3 (Zmiz1-Fzd3) promoter interaction. Endothelial cells were transfected with a Fzd3 promoter-luciferase plasmid. Polymerase chain reaction (PCR) and western blotting assessed… More >

Williams Kyei^*, Chunyong Yin, Kelvin Amos Nicodemas, Khagendra Darlami

Journal on Artificial Intelligence, Vol.8, pp. 19-38, 2026, DOI:10.32604/jai.2026.074988 - 20 January 2026

Abstract The COVID-19 pandemic has underscored the need for rapid and accurate diagnostic tools to differentiate respiratory infections from normal cases using chest X-rays (CXRs). Manual interpretation of CXRs is time-consuming and prone to errors, particularly in distinguishing COVID-19 from viral pneumonia. This research addresses these challenges by proposing a customized EfficientNet-B0 model for ternary classification (COVID-19, Viral Pneumonia, Normal) on the COVID-19 Radiography Database. Employing transfer learning with architectural modifications, including a tailored classification head and regularization techniques, the model achieves superior performance. Evaluated via accuracy, F1-score (macro-averaged), AUROC (macro-averaged), precision (macro-averaged), recall (macro-averaged), inference… More >

Longyue Li¹, Guoqing Zhang¹, Bo Cao¹, Shuqi Wang², Ye Tian^1,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-26, 2026, DOI:10.32604/cmc.2025.070622 - 09 December 2025

Abstract Modern battlefields exhibit high dynamism, where traditional static weighting methods in combat effectiveness assessment fail to capture real-time changes in indicator values, leading to limited assessment accuracy—especially critical in scenarios like sudden electronic warfare or degraded command, where static weights cannot reflect the operational value decay or surge of key indicators. To address this issue, this study proposes a dynamic adaptive weighting method for evaluation indicators based on G1-CRITIC-PIVW. First, the G1 (Sequential Relationship Analysis Method) subjective weighting method—translates expert knowledge into indicator importance rankings—leverages expert knowledge to quantify the relative importance of indicators via… More >

Asma Batool¹, Fahad Ahmed¹, Naila Sammar Naz¹, Ayman Altameem², Ateeq Ur Rehman^3,4, Khan Muhammad Adnan^5,*, Ahmad Almogren^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4129-4152, 2025, DOI:10.32604/cmes.2025.073149 - 23 December 2025

Abstract Early and accurate cancer diagnosis through medical imaging is crucial for guiding treatment and enhancing patient survival. However, many state-of-the-art deep learning (DL) methods remain opaque and lack clinical interpretability. This paper presents an explainable artificial intelligence (XAI) framework that combines a fine-tuned Visual Geometry Group 16-layer network (VGG16) convolutional neural network with layer-wise relevance propagation (LRP) to deliver high-performance classification and transparent decision support. This approach is evaluated on the publicly available Kaggle kidney cancer imaging dataset, which comprises labeled cancerous and non-cancerous kidney scans. The proposed model achieved 98.75% overall accuracy, with precision, More >

Nameer Baht^1,*, Enrique Domínguez^1,2,*

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 4441-4455, 2025, DOI:10.32604/cmc.2025.069528 - 23 October 2025

Abstract Coffee is an important agricultural commodity, and its production is threatened by various diseases. It is also a source of concern for coffee-exporting countries, which is causing them to rethink their strategies for the future. Maintaining crop production requires early diagnosis. Notably, Coffee Leaf Miner (CLM) Machine learning (ML) offers promising tools for automated disease detection. Early detection of CLM is crucial for minimising yield losses. However, this study explores the effectiveness of using Convolutional Neural Networks (CNNs) with transfer learning algorithms ResNet50, DenseNet121, MobileNet, Inception, and hybrid VGG19 for classifying coffee leaf images as… More >

Luyao Jiang^1,#, Longsheng Fu^2,#, Shaofeng Xiong^2,3, Guosheng Cao⁴, Yanqin Mei^2,3, Yaoqi Wu², Jin Chen^1,*, Yanni LV^2,5,6,*

BIOCELL, Vol.49, No.9, pp. 1749-1769, 2025, DOI:10.32604/biocell.2025.068507 - 25 September 2025

Abstract Background: After ischemic stroke, neutrophils hyperactivate, increasing in number and worsening inflammation, causing neural damage. Prior scRNA-seq showed Lrg1 modulates cells subsentence to cerebral ischemia-reperfusion injury, but its mechanism in regulating neutrophil accumulation/differentiation post-injury is unclear. Methods: Lrg1 knockout impact on neutrophil accumulation was assessed via immunofluorescence and western blot. Three-dimensional reconstruction of immunofluorescent staining analyzed cell-cell interactions among neutrophils and microglia. scRNA-seq of WT and Lrg1^-/- mice from GSE245386 and GSE279462 was conducted. Each group conducted oxidative phosphorylation scoring via Gene Set Enrichment Analysis (GSEA), while Metascape was employed to perform GO and KEGG enrichment… More > Graphic Abstract

Caiping Huang^*, Hui Li, Zihang Yu

Structural Durability & Health Monitoring, Vol.19, No.5, pp. 1287-1304, 2025, DOI:10.32604/sdhm.2025.065930 - 05 September 2025

Abstract Semantic segmentation of concrete bridge defect images frequently encounters challenges due to insufficient precision and the limited computational capabilities of mobile devices, thereby considerably affecting the reliability of bridge defect monitoring and health assessment. To tackle these issues, a concrete defects dataset (including spalling, crack, and exposed steel rebar) was curated and multiple semantic segmentation models were developed. In these models, a deep convolutional network or a lightweight convolutional network were employed as the backbone feature extraction networks, with different loss functions configured and various attention mechanism modules introduced for conducting multi-angle comparative research. The… More >

Smita Khairnar^1,2, Shilpa Gite^1,3,*, Biswajeet Pradhan^4,*, Sudeep D. Thepade^2,5, Abdullah Alamri⁶

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 3677-3707, 2025, DOI:10.32604/cmes.2025.058855 - 30 June 2025

Abstract Face liveness detection is essential for securing biometric authentication systems against spoofing attacks, including printed photos, replay videos, and 3D masks. This study systematically evaluates pre-trained CNN models— DenseNet201, VGG16, InceptionV3, ResNet50, VGG19, MobileNetV2, Xception, and InceptionResNetV2—leveraging transfer learning and fine-tuning to enhance liveness detection performance. The models were trained and tested on NUAA and Replay-Attack datasets, with cross-dataset generalization validated on SiW-MV2 to assess real-world adaptability. Performance was evaluated using accuracy, precision, recall, FAR, FRR, HTER, and specialized spoof detection metrics (APCER, NPCER, ACER). Fine-tuning significantly improved detection accuracy, with DenseNet201 achieving the highest… More > Graphic Abstract

Tawfeeq Shawly¹, Ahmed A. Alsheikhy^2,*

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4161-4179, 2025, DOI:10.32604/cmc.2025.061497 - 06 March 2025

Abstract A healthy brain is vital to every person since the brain controls every movement and emotion. Sometimes, some brain cells grow unexpectedly to be uncontrollable and cancerous. These cancerous cells are called brain tumors. For diagnosed patients, their lives depend mainly on the early diagnosis of these tumors to provide suitable treatment plans. Nowadays, Physicians and radiologists rely on Magnetic Resonance Imaging (MRI) pictures for their clinical evaluations of brain tumors. These evaluations are time-consuming, expensive, and require expertise with high skills to provide an accurate diagnosis. Scholars and industrials have recently partnered to implement… More >

Amel Ksibi^1,*, Mohammed Zakariah², Latifah Almuqren¹, Ala Saleh Alluhaidan¹

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4093-4116, 2025, DOI:10.32604/cmc.2025.059615 - 06 March 2025

Abstract The analysis of Android malware shows that this threat is constantly increasing and is a real threat to mobile devices since traditional approaches, such as signature-based detection, are no longer effective due to the continuously advancing level of sophistication. To resolve this problem, efficient and flexible malware detection tools are needed. This work examines the possibility of employing deep CNNs to detect Android malware by transforming network traffic into image data representations. Moreover, the dataset used in this study is the CIC-AndMal2017, which contains 20,000 instances of network traffic across five distinct malware categories: a.… More >