Bingqian Ding*1, Huimin Liang†1, Ming Gao*, Zhenjiang Li*, Chenyang Xu*, Shaokang Fan*, Na Chang†
Oncology Research, Vol.25, No.5, pp. 701-708, 2017, DOI:10.3727/096504016X14772378087005
Abstract The forkhead box A2 (FOXA2) is the key transcriptional factor that plays an important role in tumorigenesis.
However, until now the expression pattern and role of FOXA2 in glioma have yet to be elucidated. Therefore,
the aim of this study was to evaluate the expression of FOXA2 in glioma and investigate its role in glioma cells.
Our data showed that FOXA2 was significantly downregulated in human glioma cell lines. Forced expression
of FOXA2 suppressed the ability of glioma cells to proliferate, migrate, and invade and influenced the expression level of EMT-associated proteins. In addition, forced More >
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