Kexin Lou*1, Ning Chen†1, Zhihong Li*, Bei Zhang†, Xiuli Wang‡, Ye Chen*, Haining Xu*, Dongwei Wang*, Hao Wang*
Oncology Research, Vol.25, No.1, pp. 65-73, 2017, DOI:10.3727/096504016X14719078133366
Abstract Abnormal expression of microRNA (miR)-142-5p has been reported in hepatocellular carcinoma (HCC).
However, little information is available regarding the functional role of miR-142-5p in HCC. We aimed to
explore the effects of miR-142-5p aberrant expression on HCC cell growth and cell apoptosis, as well as the
underlying mechanism. Human HCC cell lines HepG2 and SMMC-7721 cells were transfected with miR-
142-5p mimic, inhibitor, or a corresponding negative control. Cell viability, cell cycle distribution, and cell
apoptosis were then analyzed. In addition, protein expression of Forkhead box, class O (FOXO) 1 and 3, a
Bcl-2-interacting mediator… More >
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