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    ARTICLE

    A composite noninvasive index correlates with liver fibrosis scores in post-Fontan patients: Preliminary findings

    William N. Evans1,2, Ruben J. Acherman1,2, Michael L. Ciccolo1,3, Sergio A. Carrillo1,2, Alvaro Galindo1,2, Abraham Rothman1,2, Gary A. Mayman1,2, Elizabeth A. Adams1,2, Leigh C. Reardon1,4, Brody J. Winn5, Noel S. Yumiaco5, Lesley Shimuizu1, Yoko Inanaga1, Rowena J. Deleon1, Humberto Restrepo1,2

    Congenital Heart Disease, Vol.13, No.1, pp. 38-45, 2018, DOI:10.1111/chd.12558

    Abstract Objective: We hypothesized that clinic-based, hepatic-ultrasound, elastography measurements, either alone or in combination with other noninvasive variables, might correlate with liver-biopsy fibrosis scores in patients post-Fontan.
    Methods: Between March 2012 and February 2017, we identified patients post-Fontan that underwent elective cardiac catheterization and simultaneous transvenous hepatic biopsy. From this group, we selected patients that met inclusion criteria for liver-ultrasound, shear-wave elastography. Utilizing the results of elastography, laboratory testing, and time post-Fontan, we constructed a composite Fontan hepatic index as a sum of elastography measurements in kilopascals, model for end-stage liver disease excluding INR scores, and the square… More >

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