Xuyang Wen*, Xiaoping He†, Feng Jiao‡, Chunhui Wang§, Yang Sun‡, Xuequn Ren¶, Qianwen Li*
Oncology Research, Vol.25, No.4, pp. 629-640, 2017, DOI:10.3727/096504016X14768383625385
Abstract Gastric cancer (GC) is one of the main causes of cancer death. The tumor microenvironment has a profound
effect on inducing tumor growth, metastasis, and immunosuppression. Fibroblast activation protein-a (FAP)
is a protein that is usually expressed in fibroblasts, such as cancer-associated fibroblasts, which are major
components of the tumor microenvironment. However, the role of FAP in GC progression and treatment is
still unknown. In this study, we explored these problems based on GC patient samples and experimental
models. We found that high FAP expression was an independent prognosticator of poor survival in GC
patients. More >
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