Juntao Wang, Guodong Sun

Oncology Research, Vol.25, No.9, pp. 1517-1527, 2017, DOI:10.3727/096504017X14859934460780

Abstract miR-26a has been found to be downregulated in osteosarcoma (OS) when compared with normal control tissues and has been shown to suppress the malignant behaviors of OS cells. The underlying mechanism, nevertheless, remains unknown. In our study, the long noncoding RNA MALAT1, confirmed to be significantly upregulated in OS, is first shown to be capable of promoting proliferation and migration by directly suppressing miR-26a-5p in OS cells. In addition, we have identified forkhead box O1 (FOXO1) as a transcriptional factor of MALAT1 that can negatively regulate MALAT1. We have shown that MALAT1 promoted growth and More >

Dandan Li^*, Changjun He^†, Junfeng Wang^†, Yanbo Wang^†, Jianlong Bu^†, Xianglong Kong^†, Dawei Sun^†

Oncology Research, Vol.26, No.3, pp. 385-400, 2018, DOI:10.3727/096504017X14973124850905

Abstract Many studies have shown that downregulation of miR-138 occurs in a variety of cancers including non-small cell lung cancer (NSCLC). However, the precise mechanisms of miR-138 in NSCLC have not been well clarified. In this study, we investigated the biological functions and molecular mechanisms of miR-138 in NSCLC cell lines, discussing whether it could turn out to be a therapeutic biomarker of NSCLC in the future. In our study, we found that miR-138 is downregulated in NSCLC tissues and cell lines. Moreover, the low level of miR-138 was associated with increased expression of SOX4 in… More >

Zohaib Ahmad Khan¹, Yuanqing Xia^1,*, Ahmed Khan², Muhammad Sadiq², Mahmood Alam³, Fuad A. Awwad⁴, Emad A. A. Ismail⁴

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2771-2793, 2024, DOI:10.32604/cmc.2024.046897

Abstract Sentiment analysis is becoming increasingly important in today’s digital age, with social media being a significant source of user-generated content. The development of sentiment lexicons that can support languages other than English is a challenging task, especially for analyzing sentiment analysis in social media reviews. Most existing sentiment analysis systems focus on English, leaving a significant research gap in other languages due to limited resources and tools. This research aims to address this gap by building a sentiment lexicon for local languages, which is then used with a machine learning algorithm for efficient sentiment analysis.… More >

Xuechuan Wang¹, Wei He^1,*, Haoyang Feng¹, Satya N. Atluri²

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1263-1294, 2024, DOI:10.32604/cmes.2023.043068

Abstract Although predictor-corrector methods have been extensively applied, they might not meet the requirements of practical applications and engineering tasks, particularly when high accuracy and efficiency are necessary. A novel class of correctors based on feedback-accelerated Picard iteration (FAPI) is proposed to further enhance computational performance. With optimal feedback terms that do not require inversion of matrices, significantly faster convergence speed and higher numerical accuracy are achieved by these correctors compared with their counterparts; however, the computational complexities are comparably low. These advantages enable nonlinear engineering problems to be solved quickly and accurately, even with rough… More > Graphic Abstract

Changtao Wang, Honghua Dai^*, Wenchuan Yang

Digital Engineering and Digital Twin, Vol.1, pp. 3-13, 2023, DOI:10.32604/dedt.2023.044210

Abstract A novel Adaptive Parallel Feedback-Accelerated Picard Iteration (AP-FAPI) method is proposed to meet the requirements of various aerospace missions for fast and accurate orbit propagation. The Parallel Feedback-Accelerated Picard Iteration (P-FAPI) method is an advanced iterative collocation method. With large-step computing and parallel acceleration, the P-FAPI method outperforms the traditional finite-difference-based methods, which require small-step and serial integration to ensure accuracy. Although efficient and accurate, the P-FAPI method suffers extensive trials in tuning method parameters, strongly influencing its performance. To overcome this problem, we propose the AP-FAPI method based on the relationship between the parameters More >

Yuzheng Yang^*, Zhe Tu, Ying Liu, Huachun Zhou

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3163-3184, 2023, DOI:10.32604/cmc.2023.043974

Abstract Currently, data security and privacy protection are becoming more and more important. Access control is a method of authorization for users through predefined policies. Token-based access control (TBAC) enhances the manageability of authorization through the token. However, traditional access control policies lack the ability to dynamically adjust based on user access behavior. Incorporating user reputation evaluation into access control can provide valuable feedback to enhance system security and flexibility. As a result, this paper proposes a blockchain-empowered TBAC system and introduces a user reputation evaluation module to provide feedback on access control. The TBAC system… More >

Rongrong Ren^1,2, Luyang Su^1,2, Xinyu Meng^1,2, Jianfang Wang³, Meng Zhao^1,2,4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 429-458, 2024, DOI:10.32604/cmes.2023.027310

Abstract With the development of big data and social computing, large-scale group decision making (LGDM) is now merging with social networks. Using social network analysis (SNA), this study proposes an LGDM consensus model that considers the trust relationship among decision makers (DMs). In the process of consensus measurement: the social network is constructed according to the social relationship among DMs, and the Louvain method is introduced to classify social networks to form subgroups. In this study, the weights of each decision maker and each subgroup are computed by comprehensive network weights and trust weights. In the… More >

RUI ZHANG^1,2,#, PENG ZHOU^1,3,#, XIA OU⁴, PEIZHU ZHAO², XIJING GUO², MIAN XI^5,*, CHEN QING^1,*

Oncology Research, Vol.31, No.6, pp. 887-897, 2023, DOI:10.32604/or.2023.030184

Abstract Esophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in patients worldwide. Resistance to immunotherapy and chemotherapy results in worse survival outcomes in ESCC. It is urgent to explore the underlying molecular mechanism of immune evasion and chemoresistance in ESCC. Here, we conducted RNA-sequencing analysis in ten ESCC tissues from cisplatin-based neoadjuvant chemotherapy patients. We found that DMRTA1 was extremely upregulated in the non-pathologic complete response (non-pCR) group. The proliferation rate of esophageal squamous carcinoma cells was markedly decreased after knockdown of DMRTA1 expression, which could increase cisplatin sensitivity in More >

Shuiping Zhang^1,2, Xi Liang³, Lin Shi², Lei Yan⁴, Jun Tang^1,2,*

Sound & Vibration, Vol.57, pp. 29-44, 2023, DOI:10.32604/sv.2023.041350

Abstract The filter-x least mean square (FxLMS) algorithm is widely used in active noise control (ANC) systems. However, because the algorithm is a feedback control algorithm based on the minimization of the error signal variance to update the filter coefficients, it has a certain delay, usually has a slow convergence speed, and the system response time is long and easily affected by the learning rate leading to the lack of system stability, which often fails to achieve the desired control effect in practice. In this paper, we propose an active control algorithm with nearest-neighbor trap structure… More > Graphic Abstract

R. Vanalakshmi¹, S. Maragathasundari^1,*, M. Kameswari¹, B. Balamurugan², C. Swedheetha³

Intelligent Automation & Soft Computing, Vol.37, No.2, pp. 1399-1419, 2023, DOI:10.32604/iasc.2023.038506

Abstract Queuing models are used to assess the functionality and aesthetics of SCADA systems for supervisory control and data collection. Here, the main emphasis is on how the queuing theory can be used in the system’s design and analysis. The analysis’s findings indicate that by using queuing models, cost-performance ratios close to the ideal might be attained. This article discusses a novel methodology for evaluating the service-oriented survivability of SCADA systems. In order to evaluate the state of service performance and the system’s overall resilience, the framework applies queuing theory to an analytical model. As a More >