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    ABSTRACT

    Impact of Plaque Erosion on Stress/Strain and Flow Shear Stress Calculation: An OCT-Based FSI Modeling Study

    Liang Wang1, Haibo Jia2, Luping He2, Rui Lv1, Xiaoya Guo3, Chun Yang4,5, Don P. Giddens6,7, Habib Samady6, Akiko Maehara8, Gary S. Mintz8, Dalin Tang1,*,5

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 23-24, 2019, DOI:10.32604/mcb.2019.07522

    Abstract Plaque erosion, one of the primary causes for coronary thrombosis, is responsible for about one third of the patients with acute coronary syndrome (ACS) [1]. Histological studies characterized the eroded plaque as a plaque with following morphological features: 1) plaque intima having direct contact with intraluminal thrombus due to the absence of endothelium or endothelial injury; 2) without rupture in the fibrous cap; 3) abundance of proteoglycans and smooth muscle cells on the luminal surface under the thrombus [2]. These characteristics has been applied in in vivo diagnosis of plaque erosion using optical coherence tomography… More >

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