YIWEN ZHU¹, LIU YANG¹, YING YU¹, YING XIONG², PING XIAO², XIAO FU², XIN LUO^2,*

Oncology Research, Vol.32, No.5, pp. 899-910, 2024, DOI:10.32604/or.2023.042604

Abstract Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis. Since there is no permanent therapy for this condition, it is necessary to develop a cure. Therefore, this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A (HYSA) in osteosarcoma cell lines (MG63). In this investigational study, MG63 cells were utilized. Microarray experiments, quantitative polymerase chain reaction (qPCR), immunofluorescent staining, extracellular acidification rate (ECAR), oxygen consumption rate (OCR), glucose consumption, lactate production, and ATP levels, proliferation assay, 5-Ethynyl-2′-deoxyuridine (EDU) staining, and Western… More >

Ying Zhang¹, Wei Li^1,*, Guidong Yang¹, Snezana Kirin²

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.3, pp. 2177-2199, 2024, DOI:10.32604/cmes.2023.030728

Abstract The Mean First-Passage Time (MFPT) and Stochastic Resonance (SR) of a stochastic tumor-immune model with noise perturbation are discussed in this paper. Firstly, considering environmental perturbation, Gaussian white noise and Gaussian colored noise are introduced into a tumor growth model under immune surveillance. As follows, the long-time evolution of the tumor characterized by the Stationary Probability Density (SPD) and MFPT is obtained in theory on the basis of the Approximated Fokker-Planck Equation (AFPE). Herein the recurrence of the tumor from the extinction state to the tumor-present state is more concerned in this paper. A more… More >