Huasong Liu*1, Jun Zhang*1, Xiangyu Luo*, Min Zeng*, Liqiang Xu*, Qunxian Zhang*, Hua Liu*, Jialong Guo*, Lanlan Xu†
Oncology Research, Vol.28, No.1, pp. 65-73, 2020, DOI:10.3727/096504019X15656904013079
Abstract Emerging evidence has demonstrated that long noncoding RNAs (lncRNAs) mediate the development of
esophageal squamous cell carcinoma (ESCC) via various pathophysiological pathways. This study explored the
impact of the lncRNA FOXD2-AS1 on cisplatin resistance in ESCC and its possible mechanisms. Upregulation
of FOXD2-AS was detected in patients with ESCC and ESCC cells that are resistant to cisplatin. In an in vitro
assay, knockdown of FOXD2-AS1 noticeably inhibited cell invasion and growth, triggered cell death, and
repressed the stimulation of the Akt/mTOR axis in cisplatin-resistant ESCC cells (TE-1/DDP). Conversely,
the overexpression of FOXD2-AS1 remarkably increased cell More >
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