Xiang Zhou*1, Weiming Wang†1, Pihong Li*, Zhiqiang Zheng*, Yangyang Tu*, Yi Zhang*, Tao You*
Oncology Research, Vol.23, No.1-2, pp. 29-34, 2015, DOI:10.3727/096504015X14452563486011
Abstract Despite the efficacy of fluoropyrimidines and oxaliplatin-based chemotherapy for patients, this treatment leads to
significant patient inconvenience, toxicity, and cost. This study aims to validate a nontoxic agent, curcumin, to
the current chemotherapeutic regimen. In in vitro experiments, curcumin induced apoptosis in gastric cancer cell
line BGC-823. Synergistic antitumor effects of curcumin were observed in combination with 5-fluorouracil (5-FU)
and oxaliplatin. These effects were accompanied by downregulation of the expression of Bcl-2 protein and mRNA
and upregulation of the expression of Bax and caspase 3, 8, and 9. In addition, the in vivo study showed More >
Login
Register
