QIN LIU^1,#, CHUNYAN NIU^2,#,*, QIANG ZHANG³, SHIQIN SUN⁴, YUE CHEN², YONGQIANG SHI²

BIOCELL, Vol.48, No.5, pp. 759-769, 2024, DOI:10.32604/biocell.2024.048551 - 06 May 2024

Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is a global health concern with the acid sphingomyelinase (ASM)/ceramide (CE) pathway and the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome identified as pivotal players in lipid disorders and inflammation. This study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models, aiming to understand the impact of amitriptyline (Ami), an ASM inhibitor, on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 pathway. Methods: HepG2 and HL-7702 cells were exposed to free fatty acids (FFAs) to establish the NAFLD model. The cells… More >

Chengsheng Yuan^1,2, Baojie Cui^1,2, Zhili Zhou³, Xinting Li^4,*, Qingming Jonathan Wu⁵

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 899-914, 2024, DOI:10.32604/cmc.2023.045854 - 30 January 2024

Abstract In recent years, deep learning has been the mainstream technology for fingerprint liveness detection (FLD) tasks because of its remarkable performance. However, recent studies have shown that these deep fake fingerprint detection (DFFD) models are not resistant to attacks by adversarial examples, which are generated by the introduction of subtle perturbations in the fingerprint image, allowing the model to make fake judgments. Most of the existing adversarial example generation methods are based on gradient optimization, which is easy to fall into local optimal, resulting in poor transferability of adversarial attacks. In addition, the perturbation added… More >

Jie Chen¹, Chengsheng Yuan^1,2,*, Chen Cui², Zhihua Xia¹, Xingming Sun^1,3, Thangarajah Akilan⁴

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 719-733, 2022, DOI:10.32604/cmc.2022.027984 - 18 May 2022

Abstract Fingerprint identification systems have been widely deployed in many occasions of our daily life. However, together with many advantages, they are still vulnerable to the presentation attack (PA) by some counterfeit fingerprints. To address challenges from PA, fingerprint liveness detection (FLD) technology has been proposed and gradually attracted people's attention. The vast majority of the FLD methods directly employ convolutional neural network (CNN), and rarely pay attention to the problem of over-parameterization and over-fitting of models, resulting in large calculation force of model deployment and poor model generalization. Aiming at filling this gap, this paper… More >

FUJI YANG¹, YAN HUANG¹, YOUWEN TAN^2,*, YONGMIN YAN^1,*

BIOCELL, Vol.46, No.2, pp. 389-400, 2022, DOI:10.32604/biocell.2021.015899 - 20 October 2021

Abstract Nonalcoholic fatty liver disease (NAFLD) is a long-lasting condition that affects the liver, destroying its function. Liver injury can cause steatosis and inflammation, and further activation of hepatic stellate cells (HSCs) often leads to the development of nonalcoholic liver fibrosis. The patient with NAFLD is at risk of developing advanced liver disease and complications, such as liver failure, hepatocellular carcinoma (HCC), and portal hypertension. Although our understanding of the cellular and molecular mechanisms of NAFLD has greatly improved in recent years, treatment remains limited. Analysis and characterization of protein posttranslational modifications (PTMs) could improve our More >

YUE WANG^1,#, YINPING DUAN^1,#, KUNLIN CHEN³, HUIXIA LI^1,2,*, YAN QUAN^4,*

BIOCELL, Vol.45, No.2, pp. 307-316, 2021, DOI:10.32604/biocell.2021.014305 - 19 February 2021

Abstract Non-alcoholic fatty liver disease is the most common cause of hepatic dysfunction. In the present study, human normal hepatocyte L02 cells were treated with 50% fetal bovine serum to induce the formation of hepatic steatosis in vitro, and then the cells were treated with docosahexaenoic acid to investigate its protective effect on Non-alcoholic fatty liver disease. Our results showed that 50% of fetal bovine serum significantly induced intracellular lipid accumulation and hepatocyte fatty degeneration within 48 h. The expression level of adipose formation-related genes was significantly up-regulated, such as PPARγ, C/EBPα and SREBP-1; meanwhile, the content… More >