Meng Lu1, Yi Miao1, Lan Qi, Mingzhu Bai, Jiarong Zhang, Youji Feng
Oncology Research, Vol.23, No.6, pp. 267-274, 2015, DOI:10.3727/096504016X14549667333963
Abstract FKBP14 belongs to the family of FK506-binding proteins (FKBPs). Altered expression of FKBPs has been
reported in several malignancies. This study aimed to reveal the expression profile of FKBP14 in ovarian cancer and evaluate whether FKBP14 is a molecular target for cancer therapy. We found that the FKBP14 mRNA
level was significantly higher in ovarian cancer tissues than in normal tissues. FKBP14 expression was then
knocked down in two ovarian cancer cell lines, SKOV3 and HO8910 cells, by a lentiviral short hairpin RNA
(shRNA) delivery system. Reduced expression of FKBP14 markedly impaired the proliferative ability More >
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